Application of tangerine peel extract in preparation of drugs for curing pulmonary fibrosis

A technology of tangerine peel extract and pulmonary fibrosis, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., and can solve the problems of lung fibroblasts without tangerine peel, stimulating expectoration, etc.

Inactive Publication Date: 2009-10-14
JIANGSU PROVINCIAL HOSPITAL OF TCM
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the pharmacological research of dried tangerine peel and its active ingredients on the lung, only the volatile oil of tan

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of tangerine peel extract in preparation of drugs for curing pulmonary fibrosis
  • Application of tangerine peel extract in preparation of drugs for curing pulmonary fibrosis
  • Application of tangerine peel extract in preparation of drugs for curing pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Preparation of tangerine peel extract: The specific preparation method is as follows: ①Crush the dried tangerine peel into a coarse powder, add appropriate amount of distilled water, soak the surface of the medicinal material for about 1-2 cm, heat, reflux for 1 hour, and filter while it is hot. Add an appropriate amount of distilled water to the dregs, heat and reflux in the same way, filter while it is hot, and combine the filtrates. ② The filtrate was concentrated under reduced pressure, and freeze-dried to obtain dried orange peel extract powder, hereinafter referred to as water extract.

Embodiment 2

[0014] Preparation of tangerine peel extract: The specific preparation method is as follows: ① crush the dried tangerine peel into coarse powder, add appropriate amount of 75% ethanol, soak the surface of the medicinal material for about 1-2 cm, heat, reflux for 1 hour, and filter while it is hot. Add an appropriate amount of 75% ethanol to the dregs and decoct in the same way, and combine the filtrates. ② Concentrate the filtrate under reduced pressure and freeze-dry to obtain dry powder of orange peel extract, hereinafter referred to as alcohol extract.

Embodiment 3

[0016] Preparation of tangerine peel extract: The specific preparation method is as follows: dried tangerine peel is crushed into a coarse powder, the volatile oil is extracted by steam distillation repeatedly, the distillate is combined and extracted with ether, the ether solution is collected, evaporated to dryness, and the tangerine peel extract is obtained, hereinafter referred to as volatile oil.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides the application of tangerine peel extract in the preparation of drugs for curing pulmonary fibrosis, which can effectively reduce the collagen deposition and retard the fibrosis course. Particularly, the tangerine peel extract is extract obtained by adding tangerine peel to solvent, heating and refluxing, or volatile oil obtained by subjecting tangerine peel to steam distillation. The method for preparing the tangerine peel extract comprises the following steps: (1) pulverizing dry tangerine peel into powder, adding solvent to the powder until the tangerine peel is soaked 1cm to 2cm into the solvent from the surface thereof, heating and refluxing for one hour, and filtering before the tangerine peel is cooled; (2) further adding solvent to the residue by the method in step (1), heating, refluxing and filtering before the residue is cooled; (3) merging the filtrates obtained in steps (1) and (2), vacuum-concentrating and drying the filtrates to obtain the dry tangerine peel extract powder. The invention can reduce the content of hydroxyproline in sera and lungs, which is a biological index closely related to fibrosis, reduce the expression level of transforming growth factors, that is, beta1 protein and messenger ribonucleic acid (mRNA) in lung tissues, effectively inhibit human embryonic lung fibroblasts (HELF) from proliferating and retard the production of pulmonary alveolitis and the course of pulmonary fibrosis.

Description

technical field [0001] The invention relates to the application of tangerine peel extract in preparing medicine for treating pulmonary fibrosis. Background technique [0002] Idiopathic pulmonary fibrosis (Idiopathic Pulmonary Fibrosis, IPF) is a special type of chronic interstitial pneumonia confined to the lungs of unknown cause, with progressive dyspnea as the prominent clinical manifestation, and its pathological changes are common Type interstitial pneumonia, characterized by damage to the alveolar epithelium, proliferation of fibroblasts, and formation of fibroblast foci. Chest imaging showed diffuse reticular, reticulated nodular shadows, or honeycomb-like changes, especially in the subpleura surrounding the middle and lower lung fields, while ground-glass changes were rare. Pulmonary function showed restrictive ventilatory dysfunction and / or impaired diffusion, leading to hypoxemia. In recent years, with the gradual deepening of research on pulmonary interstitial d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/752A61P11/00A61K131/00
Inventor 周贤梅
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap