Application of tangerine peel extract in preparation of drugs for curing pulmonary fibrosis

Abstract

The invention provides the application of tangerine peel extract in the preparation of drugs for curing pulmonary fibrosis, which can effectively reduce the collagen deposition and retard the fibrosiscourse. Particularly, the tangerine peel extract is extract obtained by adding tangerine peel to solvent, heating and refluxing, or volatile oil obtained by subjecting tangerine peel to steam distillation. The method for preparing the tangerine peel extract comprises the following steps: (1) pulverizing dry tangerine peel into powder, adding solvent to the powder until the tangerine peel is soaked 1cm to 2cm into the solvent from the surface thereof, heating and refluxing for one hour, and filtering before the tangerine peel is cooled; (2) further adding solvent to the residue by the method in step (1), heating, refluxing and filtering before the residue is cooled; (3) merging the filtrates obtained in steps (1) and (2), vacuum-concentrating and drying the filtrates to obtain the dry tangerine peel extract powder. The invention can reduce the content of hydroxyproline in sera and lungs, which is a biological index closely related to fibrosis, reduce the expression level of transforming growth factors, that is, beta1 protein and messenger ribonucleic acid (mRNA) in lung tissues, effectively inhibit human embryonic lung fibroblasts (HELF) from proliferating and retard the productionof pulmonary alveolitis and the course of pulmonary fibrosis.

Description

Technical field [0001] The invention relates to the application of dried tangerine peel extract in preparing medicines for treating pulmonary fibrosis. Background technique [0002] Idiopathic Pulmonary Fibrosis (IPF) is a special type of chronic interstitial pneumonia confined to the lungs of unknown cause, with progressive dyspnea as the prominent clinical manifestation. Its pathological changes are ordinary Type of interstitial pneumonia is characterized by alveolar epithelial injury, fibroblasts proliferation, and the formation of fibroblast foci. The chest imaging showed diffuse reticulation, nodules shadow or honeycomb-like changes, with the subpleural surrounding the middle and lower lung fields as the most important, while the ground-glass-like changes were less. Pulmonary function presents restrictive ventilatory dysfunction and / or impaired diffusion function, leading to hypoxemia. In recent years, with the gradual deepening of research on pulmonary interstitial diseas...

AI Technical Summary

Problems solved by technology

In the pharmacological research of dried tangerine peel and its active ingredients on the lung, only the volatile oil of tangerine peel has been found to have stimulating and expectorant effects. Research Report on the Function of Lung Fibroblasts

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