Fotemustine solid lipid nanoparticle and preparation method thereof

A technology of solid lipid nanometer and fomaustine, which is applied in the field of pharmacy, can solve the problems of difficulty in industrialized production of instruments and equipment, limited continuous application, poor product stability, etc., so as to improve the chemical stability and curative effect of medicines, and improve the bioavailability. high efficiency and low cost
CN101606907AInactive Publication Date: 2009-12-23SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2009-12-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a fotemustine solid lipid nanoparticle for injection and oral administration. The nanoparticle is characterized in that a lipid material and an emulsifier are used to encapsulate the fotemustine to prepare the fotemustine solid lipid nanoparticle with small particle diameter, high encapsulation rate, good stability and low toxicity. The prepared fotemustine solid lipid nanoparticle improves the solubility and the stability of the fotemustine, reduces vascular stimulation of the fotemustine, and prolongs the circulating time of the medicament in blood, thereby improving the curative effect of medicaments, and ensuring that preparations made of the solid lipid nanoparticle have the characteristics of low toxicity, low fotemustine solid lipid nanoparticle with low stimulation and high efficiency. The invention also relates to a method for preparing the fotemustine solid lipid nanoparticle, which has simple preparation process and low cost, and is applicable to industrial production.
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Claims

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