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Cornu-like polypeptide with antioxidant activity, separation method and application thereof

An anti-oxidant activity and pharmaceutical technology, applied in the field of medicine, can solve the problems of weak research on the material basis of the effect and the mechanism of action, and achieve the effect of good antioxidant activity, small molecular weight of the polypeptide, and clear amino acid sequence

Active Publication Date: 2010-04-14
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

[0004] Although rhino (wide) horn, antelope horn, buffalo horn and other horn medicinal materials have been used for more than a thousand years, due to the particularity of the source, material, and composition of the medicinal materials, the research on the material basis and mechanism of their effects is still relatively weak. Almost zero coverage of active ingredients

Method used

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  • Cornu-like polypeptide with antioxidant activity, separation method and application thereof
  • Cornu-like polypeptide with antioxidant activity, separation method and application thereof
  • Cornu-like polypeptide with antioxidant activity, separation method and application thereof

Examples

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Embodiment 1

[0035] (1) Preparation of buffalo horn extract:

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Abstract

The invention relates to the technical field of medicines, in particular to cornu-like polypeptide with antioxidant activity and a separation method and application thereof. The polypeptide of the invention has following sequential structures: Gln-Tyr-Asp-Gln-Gly-Val; Tyr-Glu-Asp-Cys-Thr-Asp-Cys-Gly-Asn; Ala-Ala-Asp-Asn-Ala-Asn-Glu-Leu-Phe-Pro-Pro-Asn. The polypeptide of the three sequences is extracted and separated from buffalo cornus. Pharmacological tests prove that the polypeptide has fine antioxidant activity.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to a class of horn-like polypeptides with antioxidant activity, a separation method and application thereof. Background technique [0002] Horn-like animal medicinal materials are an important part of the motherland's medical treasure house, with definite efficacy and outstanding characteristics. The earliest known herbal book in China, "Shen Nong's Materia Medica", has recorded the nature, taste and efficacy of rhinoceros horn (Cornu Rhinoceri Asiatici) and antelope horn (Cornu Saigae Tataricae), and then appeared in "Famous Doctors" in the Han Dynasty. The records of the nature, taste and efficacy of horn (Cornu Bubali). For thousands of years, rhinoceros horns, antelope horns, buffalo horns and other horn medicinal materials have been indispensable medicines in Chinese medicine, mainly used to treat heat syndrome. However, the current law has explicitly prohibited the use and t...

Claims

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Application Information

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IPC IPC(8): C07K7/06C07K7/08C07K1/14A61K38/08A61K38/10A61P39/06
Inventor 段金廒刘睿钱大玮唐于平郭建明
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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