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Preparation method of lansoprazole solid preparation
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A lansoprazole solid and a technology for lansoprazole are applied in the field of preparation of lansoprazole solid preparations, can solve problems such as poor product content uniformity, achieve content uniformity and stability control, facilitate operation, simple craftsmanship
Active Publication Date: 2013-06-19
YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD +1
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But, the contriver finds that the content uniformity of the product made by this method is not good
Method used
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Embodiment 1
[0079] 1. The composition of the tablet core, as shown in Table 12:
[0083] ① Dissolve NaOH, PVP K30, and Lansoprazole in the prescribed amount in absolute ethanol in turn, stir to make the solution clear, and use it as an adhesive for later use;
[0084] ②Take the prescribed amount of MCC and CCMC-Na, mix them, and granulate them in one step to control the moisture content below 3%.
[0085] ③Through granulation, pass through a 16-mesh sieve, add appropriate amount of magnesium stearate and talcum powder, mix evenly, and press into t...
Embodiment 2
[0089] 1. The composition of the tablet core, as shown in Table 13:
[0097] 2. The tablet core preparation method and coating process are the same as in Example 1.
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Abstract
The invention belongs to the field of pharmacy, relating to a preparation method of a lansoprazole solid preparation, and solving the technical problem of providing a preparation method capable of ensuring a favorable content uniformity of the lansoprazole solid preparation. The preparation method comprises the following steps of: A, sequentially dissolving an alkaline material and the lansoproazole into anhydrous ethyl alcohol to obtain a mixed solution for later use; B, dissolving a bulking agent into the mixed solution obtained in the step A, and pelletizing; and C, preparing a solid preparation by processing particles obtained from the pelletizing according to a traditional method. The preparation method of the solid preparation has the advantages of little used auxiliary material, simple process, and convenient operation; and after long-time production practice, the content uniformity and stability of products can be commendably controlled.
Description
technical field [0001] The invention belongs to the field of pharmacy, and relates to a preparation method of lansoprazole solid preparation. Background technique [0002] Compared with the first-generation proton pump inhibitor omeprazole, lansoprazole has the following advantages: [0003] 1. Relieve symptoms quickly and effectively: because fluorine is introduced into the molecular structure, its bioavailability is increased by 25%; chemical stability and fat solubility are also increased, so that its active effect can take effect faster; There are 3 binding points between the drug and the proton pump, so the effect of inhibiting the proton pump is more complete, and the inhibition of gastric acid secretion is faster and more obvious. [0004] 2. High cure rate: the cure rate for duodenal ulcer and reflux esophagitis is over 90%. [0005] 3. Convenience in taking medicine: it can be administered once a day (30mg). [0006] 4. Good cost performance: the cost of treatmen...
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