Application of Morphine in preparing medicaments for treating Parkinson disease

A technology for 1. morphine and Parkinson's disease, applied in the field of medicine, can solve problems such as no morphine neuron damage

Inactive Publication Date: 2010-07-07
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Morphine protects neurons from MPP, so far not seen in the prior art + Reports on the role of injury

Method used

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  • Application of Morphine in preparing medicaments for treating Parkinson disease
  • Application of Morphine in preparing medicaments for treating Parkinson disease
  • Application of Morphine in preparing medicaments for treating Parkinson disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: 250 mg of Morphine (Morphine purchased from Shenyang No. 1 Pharmaceutical Factory) was dissolved in 1000 ml of water to make a 0.25% concentration of aqueous solution, heated and dissolved, mixed evenly, sealed in a medicine bottle, and sterilized to make a product.

Embodiment 2

[0015] Embodiment 2: 125 mg of Morphine (Morphine purchased from Shenyang No. 1 Pharmaceutical Factory) was dissolved in 1000 ml of water to make an aqueous solution with a concentration of 0.125% and heated for dissolving.

Embodiment 3

[0016] Embodiment 3: 2500 mg of Morphine (Morphine purchased from Shenyang No. 1 Pharmaceutical Factory) was dissolved in 1000 ml water to make an aqueous solution, heated to dissolve, mixed evenly, and then divided into injections with a concentration of 5 mg / 2ml / branch and sealed in a medicine bottle. Sterilize finished product.

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PUM

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Abstract

The invention relates to an application of Morphine in preparing medicaments for treating the Parkinson disease, in particular to a new medical application of Morphine, belonging to the technical field of medicines. Through a thiazolyl blue (MTT) method, the Morphine is found to be capable of promoting the growth of adrenal gland chromaffin tumor cells (PC12 cells) of rats. The Morphine has the activity of promoting the proliferation of nerve cells and can inhibit nerve cell injuries caused by a Parkinson toxic substance MPP+(1-Methyl-4-Phenylpyridiniumion). Proved by a protein immunoblotting method, the Morphine can induce the expression level of thioredoxin in the PC12 cells, thus the Morphine for protecting the nerve cells from injuries of MPP+ toxicity is related to the induction of the expression of the thioredoxin.

Description

Technical field: [0001] The invention relates to the application of Morphine in the preparation of medicines for treating Parkinson's disease, specifically relates to the new medical application of Morphine, and belongs to the technical field of medicine. Background technique: [0002] Morphine is the most important alkaloid in opium, and low concentration of morphine can protect nerve cells from ischemia-reperfusion injury. Ischemia-reperfusion followed by morphine preconditioning significantly improved neuronal survival. This protective effect is achieved through the activation of opioid receptors (Lim, YJ, Zheng, S and Zuo, Z. Morphinepreconditions Purkinje cells against cell death under in vitro simulateddischemiareperfusion conditions. Anesthesiology 2004; 100: 562-568). Therefore, the protective effect of morphine on neurons may have a very positive effect on clinical medicine. However, the role of morphine in protecting neurons from MPP+ has not been reported. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61P25/16
Inventor 白洁陈妍
Owner KUNMING UNIV OF SCI & TECH
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