Method for detecting carbamazepine

A carbamazepine and detection method technology, which is applied in the field of carbamazepine detection, can solve problems such as skin and internal organ damage, and achieve high specificity and accurate determination effects

Active Publication Date: 2011-09-14
杭州金域医学检验所有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Carbamazepine has many side effects, including: Potentially life-threatening allergic reactions; Toxic to the trigeminal nerve; May cause serious damage to the skin and internal organs

Method used

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  • Method for detecting carbamazepine
  • Method for detecting carbamazepine
  • Method for detecting carbamazepine

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0020] A method for detecting carbamazepine, comprising the following steps:

[0021] 1) contacting the sample to be tested with the specific antibody against carbamazepine;

[0022] 2) According to the combination of the substance in the sample to be tested and the antibody, determine the content of carbamazepine in the sample,

[0023] Wherein the anti-carbamazepine specific antibody is obtained by immunizing animals with a carbamazepine immunogen, and the structural formula of the carbamazepine immunogen is shown in (I):

[0024]

[0025] In the formula, R is a linking group, and the carrier has immunogenicity.

[0026] Preferably, the carrier is an immunogenic protein. Proteins are usually the carrier of choice, although other sufficiently large immunogenic substances can also be used as carriers. The most commonly used immunogenic carriers include serum albumin, hemocyanin (KLH) and thyroglobulin. The choice of carrier is the basic common sense of those skilled in ...

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PUM

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Abstract

The invention discloses a method for detecting carbamazepine. The method comprises the following steps of: contacting a sample to be detected and a carbamazepine specificity antibody; and determining the content of the carbamazepine in the sample according to combination of a substance in the sample to be detected and the antibody, wherein the carbamazepine specificity antibody is obtained from a carbamazepine immunogen immune animal. The detection method is high in specificity; and by the method, the carbamazepine and the content of the carbamazepine in the sample to be detected can be determined accurately.

Description

technical field [0001] The invention relates to a detection method, in particular to a detection method of carbamazepine. Background technique [0002] Carbamazepine (5 H -dibenzo[ b , f ]azepine-5-carboxamide, 5H-dibenzo[b,f]azepine-5-carboxamide), its structural formula is shown in formula (II). [0003] [0004] Carbamazepine is a class of antiepileptic and mood stabilizing drugs, mainly used in the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. Carbamazepine has many side effects, including: anaphylaxis that may be life-threatening; toxicity to the trigeminal nerve that may cause severe damage to the skin and internal organs. It is therefore very important to monitor the patient's blood drug levels during treatment. Contents of the invention [0005] The object of the present invention is to provide a method for detecting carbamazepine. [0006] The technical scheme that the present invention takes is: [0007] A method for detecting carbam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
Inventor 虞留明梁耀铭李洪波
Owner 杭州金域医学检验所有限公司
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