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A synergist with synergistic antifungal effect with fluconazole

A fluconazole and antifungal technology, applied in the field of enhancing the antifungal activity of fluconazole, can solve the problems of increased drug resistance of fungi

Inactive Publication Date: 2011-12-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

In recent years, the irrational use of broad-spectrum antibiotics in clinical practice has also made the drug resistance of fungi continue to increase

Method used

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  • A synergist with synergistic antifungal effect with fluconazole
  • A synergist with synergistic antifungal effect with fluconazole
  • A synergist with synergistic antifungal effect with fluconazole

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Embodiment Construction

[0013] Reference literature (National committee for clinical laboratory standards. Reference method for broth dilution antifungal susceptibility testing of yeast; Approved Standard M27-A. Lancaster Avenue, Villanova. Pennsylvania: CLSI, 1997.1-12); (Odds F C, Synergy, and what the Chequerboard puts between them, J Antimicrob Chemother (2003) 52, 1); (Meletiadis J etc, In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolifican isolates, Antimicrob Agents Chemother. GM etc, Antimicrobial combination. In: Lorian V, editor. Antibiotics in Laboratory Medicine, 4th ed. Baltimore, MD: The Williams and Wilkins Co. (1996) 330-96) and (Sanati, Hetc, Combination therapy with amphotericin B and Fluconazole against invasivecandidiasis in neutropenic-mouse and infective-endocarditis rabbit models, Antimicrob Agents Chemother (1997) 1345-1348.) method for drug susceptibility experiments and collaborative experiments, the specific ope...

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Abstract

The invention discloses a novel application of honokiol and fluconazole in antifungal cooperation. According to the invention, the fungi are candida albicans. According to the invention, a standard macrodilution drug sensitivity experiment recommended by CLSI is adopted, in vitro sensitivity of honokiol towards clinically separated drug resistant candida albicans is evaluated with systematic methods such as a checkerboard macrodilution method and a time-kill curve method. Also, an in vitro synergistic effect of honokiol and fluconazole in clinic drug resistant fungi resistance is evaluated. Further, with a mice infection and treatment experiment, an in vivo synergistic effect of honokiol and fluconazole in clinic drug resistant fungi resistance is evaluated.

Description

technical field [0001] The invention relates to the application of honokiol and fluconazole in combination to enhance the antifungal activity of fluconazole. Background technique [0002] In the past two decades, fungal infections that have seriously endangered human life and health have been increasing both in terms of incidence and types of infections, especially in immunosuppressed patients. Among human fungal infections, the most important opportunistic pathogen is Candida albicans, which can cause everything from chronic skin infections to life-threatening systemic fungal infections. Candida albicans (C.albicans) is a common pathogenic fungus that can invade the skin, mucous membranes and internal organs, manifesting as acute, subacute and chronic inflammation. These infections are not only common, but also extremely harmful. Clinical candidiasis of the throat, esophagus, and vagina is often the first symptom of AIDS. In recent years, the irrational use of broad-spec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4196A61K31/05A61P31/10
Inventor 于录邓旭明金晶唐旭东郭娜梁俊超李蕾
Owner JILIN UNIV
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