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Application of a traditional Chinese medicine composition in the preparation of drugs for reducing the death of patients after myocardial infarction

A technique for myocardial infarction and a composition is applied in the field of medicine, which can solve problems such as disability and adverse reactions, and achieve the effects of improving the quality of life and the occurrence of angina pectoris.

Active Publication Date: 2011-12-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The results of large-scale drug clinical trials have confirmed that antiplatelet agents (aspirin), β-blockers, statins, lipid-lowering drugs, and angiotensin-converting enzyme inhibitors can significantly reduce the mortality rate of AMI, but There are still many survivors who are disabled or dead due to secondary cardiovascular events such as infarction, severe arrhythmia, and heart failure, and these drugs have more or less adverse reactions, and some are even serious

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of drugs for reducing the death of patients after myocardial infarction
  • Application of a traditional Chinese medicine composition in the preparation of drugs for reducing the death of patients after myocardial infarction
  • Application of a traditional Chinese medicine composition in the preparation of drugs for reducing the death of patients after myocardial infarction

Examples

Experimental program
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Effect test

Embodiment 1

[0184] Take 86.5g of Astragalus, 21.3g of Salvia, 3.5g of Panax notoginseng, 20.6g of Dalbergia odorifera, and 30g of polyethylene glycol-6000 as an auxiliary material. Decoct crushed Salvia miltiorrhiza and Panax notoginseng twice in water, add 7 times the amount of water each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let stand for 12-24 hours, filter, recover ethanol, and concentrate into extract with relative density of 1.32~1.38 (50~60℃); decoct the crushed astragalus with water twice, add 6 each time Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let stand for 12-24 hours, filter, and recover the ethanol from the filtrate and concentrate to about 400ml At the time, add 95% ethanol to make the alcohol concentration 80%, let stand for 12-2...

Embodiment 2

[0186] Take 40.6g of Astragalus, 44.8g of Salvia, 11.2g of Panax notoginseng, 38.6g of Dalbergia odorifera, 30g of adjuvant polyethylene glycol-6000, and make 1000 drop pills according to the method of Example 1 and Example 2.

Embodiment 3

[0188] Take 77.3g of Astragalus, 22.8g of Salvia miltiorrhiza, 4.8g of Panax notoginseng, 30.5g of Dalbergia odorifera, 28g of adjuvant polyethylene glycol-6000, and make 1000 drop pills according to the method of Example 1 and Example 2.

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Abstract

The present invention relates to a use of Chinese medicine composition in preparation of medicine for secondary prevention of myocardial infarction. Said Chinese medicine composition is prepared from a formula comprising the crude drugs by the following weight percentages: Radix Astragali 22.2%ˆ¼66.8%, Radix Salviae Miltiorrhizae 11.6%ˆ¼33.4%, Radix Notoginseng 2.5%ˆ¼13.5%, and Lignum Dalbergiae Odoriferae 14.5%ˆ¼44.3%.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of a traditional Chinese medicine composition in the preparation of a medicine for secondary prevention of myocardial infarction. Background technique [0002] Cardiovascular disease is a common and frequently-occurring disease that seriously threatens human life and health. Approximately one million more people die from acute cardiovascular events worldwide each year, and more than half of them die from acute myocardial infarction (AMD. With the population With the development of aging, the incidence of acute myocardial infarction in China has shown a significant upward trend, which is close to the international average. In recent years, due to the improvement of monitoring and treatment levels, the mortality rate of myocardial infarction has decreased significantly, but surviving patients have recurred myocardial infarction, The risk of acute cardiovascular events ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/00
CPCA61K36/481A61K36/48A61K36/258A61K36/537A61P9/00A61P9/04A61P9/06A61P9/10A61K2300/00
Inventor 张伯礼商洪才姚晨刘保延翁维良赵玉霞戴国华高秀梅任明张俊华曹红波毛静远胡学军金智生张军平程翼宇闫希军曲家珍王辉徐宏娟郑文科
Owner TIANJIN TASLY PHARMA CO LTD
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