Application of a traditional Chinese medicine composition in the preparation of medicines for improving the quality of life after acute myocardial infarction

A technique for myocardial infarction and a composition, applied in the field of medicine, can solve problems such as adverse reactions and disability, and achieve the effects of improving the quality of life and the attack of angina pectoris

Inactive Publication Date: 2011-12-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The results of large-scale drug clinical trials have confirmed that antiplatelet agents (aspirin), β-blockers, statins, lipid-lowering drugs, and angiotensin-converting enzyme inhibitors can significantly reduce the mortality rate of AMI, but There are still many survivors who are disabled or dead due to secondary cardiovascular events such as infarction, severe arrhythmia, and heart failure, and these drugs have more or less adverse reactions, and some are even serious

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of medicines for improving the quality of life after acute myocardial infarction
  • Application of a traditional Chinese medicine composition in the preparation of medicines for improving the quality of life after acute myocardial infarction
  • Application of a traditional Chinese medicine composition in the preparation of medicines for improving the quality of life after acute myocardial infarction

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0185] Take 86.5g of astragalus, 21.3g of salvia miltiorrhiza, 3.5g of notoginseng, 20.6g of jiangxiang, and 30g of polyethylene glycol-6000 as an auxiliary material. Decoct the crushed salvia miltiorrhiza and Panax notoginseng in water twice, adding 7 times the amount of water each time for 2 hours each time, combining the decoction liquid, filtering, and concentrating the filtrate to 900ml, adding 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, recover ethanol, concentrate into an extract with a relative density of 1.32-1.38 (50-60°C); decoct the pulverized Astragalus membranaceus twice with water, adding 6 Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml , add 95% ethanol to make the alcohol c...

Embodiment 2

[0187] Get Astragalus 40.6g, Salvia miltiorrhiza 44.8g, Panax notoginseng 11.2g, Jiangxiang 38.6g, adjuvant polyethylene glycol-6000 30g, make 1000 drop pills by the method of embodiment one and embodiment two.

Embodiment 3

[0189] Get Astragalus 77.3g, Salvia miltiorrhiza 22.8g, Radix Notoginseng 4.8g, Jiangxiang 30.5g, adjuvant polyethylene glycol-6000 28g, make 1000 drop pills by the method of embodiment one and embodiment two.

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Abstract

The present invention relates to a use of Chinese medicine composition in preparation of medicine for secondary prevention of myocardial infarction. Said Chinese medicine composition is prepared from a formula comprising the crude drugs by the following weight percentages: Radix Astragali 22.2%ˆ¼66.8%, Radix Salviae Miltiorrhizae 11.6%ˆ¼33.4%, Radix Notoginseng 2.5%ˆ¼13.5%, and Lignum Dalbergiae Odoriferae 14.5%ˆ¼44.3%.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicine for secondary prevention of myocardial infarction. Background technique [0002] Cardiovascular disease is a common and frequently-occurring disease that seriously threatens human life and health. About one million people die from acute cardiovascular events every year in the world, and more than half of them die from acute myocardial infarction (AMD. With the population With the development of aging, the incidence of acute myocardial infarction in my country has shown a clear upward trend, which is close to the international average level. In recent years, due to the improvement of monitoring and treatment levels, the mortality rate of myocardial infarction has been significantly reduced, but the recurrence of myocardial infarction, The risk of acute cardiovascular events such as conges...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
CPCA61K36/481A61K36/48A61K36/258A61K36/537A61P9/00A61P9/04A61P9/06A61P9/10A61K2300/00
Inventor 张伯礼商洪才姚晨刘保延翁维良赵玉霞戴国华高秀梅任明张俊华曹红波毛静远胡学军金智生张军平程翼宇闫希军曲家珍王辉徐宏娟郑文科
Owner TIANJIN TASLY PHARMA CO LTD
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