Coloring agent for in vitro diagnostic device
A technology for human body and chemical reagents, applied in the field of pigments, which can solve the problems of instability, affecting measurement results, high water solubility, etc.
Inactive Publication Date: 2012-01-04
HUZHOU MAIDINUOHUA MEDICAL TECH
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Problems solved by technology
As a result, the measurement results are interfered by the hemoglobin in the blood. In addition, this derivative has too high water solubility, which affects the instability of the measurement results
Method used
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[0025] A nylon membrane with an average pore size of about 1.2 microns was evenly coated with biological enzymes, dried in an oven at 50 degrees Celsius for 10 minutes, then coated with dye, and dried according to the same procedure as above. Cut into 0.5 inch squares, sandwiched between two 0.005 inch thick polyester films with a 0.25 square inch opening, drop a drop of glucose solution on the nylon film and measure with reflectance optics. The absorption peak of EMBH is at 607 nm, and the absorption peak of MBTH is at 596 nm.
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The invention relates to a coloring agent for an in vitro diagnostic device, in particular to a pigment generated through chemical oxidoreduction reaction, which can be used for quantitatively detecting biochemical substances in blood. A precursor of the coloring agent is easily combined with aromatic amines or aromatic alcohols, and the stable pigment is generated in hydrogen peroxide and oxygen environments, and cannot be interfered by protoheme in specific wavelength ranges.
Description
technical field [0001] The invention relates to a method for synthesizing a dye (3-ethanol-6-methylbenzothiazoline-(2)-hydrazone) (EMBH) used in in-vitro diagnostic medical equipment, in particular to a chemical oxidation-reduction reaction produced by A pigment that can be used to quantitatively detect biochemical substances in blood. Background technique [0002] Different kinds of redox organic dyes have been used in clinical diagnosis in hospitals. However, most of the dyes commonly used in hospital laboratories are not suitable for use in small or self-use medical equipment. Only a few specially formulated dyes have been successfully used in personal medical devices. [0003] Typically, dyes or dye precursors are formulated with an electron acceptor paired with the physiochemical substance to be measured, such as blood glucose measurements using glucose oxidase as the electron acceptor. Blood sugar and glucose oxidase exchange electrons with oxygen to produce hydroge...
Claims
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IPC IPC(8): G01N33/52C09B26/02C07D277/82
Inventor 章新陈伊卫余少炀
Owner HUZHOU MAIDINUOHUA MEDICAL TECH
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