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Baohuoside-I phospholipid complex and its preparation method

A technology of phospholipid complex and baohuoside, applied in the field of medicine, can solve the problem of low water solubility of baohuoside I, no baohuoside I phospholipid complex, no baohuoside I-hydrogenated soybean lecithin-dipalmitoyl egg Phospholipid complexes, etc.

Inactive Publication Date: 2012-01-11
贾晓斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the water solubility of baohuoside I is very low, it is difficult to administer by injection, and the oral absorption is also relatively poor.
There is no report of baohuoside I phospholipid complex, let alone the report of baohuoside I-hydrogenated soybean phospholipid-dipalmitoyl lecithin complex

Method used

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  • Baohuoside-I phospholipid complex and its preparation method
  • Baohuoside-I phospholipid complex and its preparation method
  • Baohuoside-I phospholipid complex and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The molar ratio of baohuoside I and hydrogenated soybean lecithin is 1:1. Dissolve baohuoside I and hydrogenated soybean lecithin in absolute ethanol, stir at room temperature for 1 hour, evaporate in vacuum at 40°C, remove solvent, and dry in vacuum at 40°C , that is, Debao Huoside I Phospholipid Complex.

Embodiment 2

[0023] The molar ratio of baohuoside I and soybean lecithin is 1:2. Dissolve baohuoside I and soybean lecithin in absolute ethanol, stir at room temperature for 1 hour, evaporate in vacuum at 40°C, remove the solvent, and dry in vacuum at 40°C. Depot Huoside I Phospholipid Complex.

Embodiment 3

[0025] The molar ratio of baohuoside I and saturated lecithin is 1:1, dissolve baohuoside I and saturated lecithin in ethanol, stir at room temperature for 1 hour, evaporate in vacuum at 40°C, remove the solvent, and dry in vacuum at 40°C to obtain Baohuoside I Phospholipid Complex.

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PUM

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Abstract

The invention provides a Baohuoside-I phospholipid complex and its preparation method. The Baohuoside-I phospholipid complex can be used to remarkably improve pharmaceutical properties of Baohuoside-I.

Description

technical field [0001] The invention relates to a baohuoside I phospholipid complex and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Baohuoside I, chemical name: 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone-3-O-α-L-rhamnopyranoside, is a poly Hydroxyflavonoid monomer components. Pharmacological studies have shown that baohuoside I has anti-tumor and anti-osteoporosis effects. The chemical structure is shown in (I). [0003] [0004] However, the water solubility of baohuoside I is very low, it is difficult to administer by injection, and its oral absorption is also poor. At present, there is no report of baohuoside I phospholipid complex, let alone the report of baohuoside I-hydrogenated soybean phospholipid-dipalmitoyl lecithin complex. Contents of the invention [0005] The object of the present invention is to provide a baohuoside I phospholipid complex and a preparation method thereof. [0006] For the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K47/24
Inventor 贾晓斌张振海孙娥金鑫
Owner 贾晓斌
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