Baohuoside-I phospholipid complex and its preparation method

A technology of phospholipid complex and baohuoside, applied in the field of medicine, can solve the problem of low water solubility of baohuoside I, no baohuoside I phospholipid complex, no baohuoside I-hydrogenated soybean lecithin-dipalmitoyl egg Phospholipid complexes, etc.

CN102309499AInactive Publication Date: 2012-01-11贾晓斌
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2012-01-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a Baohuoside-I phospholipid complex and its preparation method. The Baohuoside-I phospholipid complex can be used to remarkably improve pharmaceutical properties of Baohuoside-I.
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Description

technical field

[0001] The invention relates to a baohuoside I phospholipid complex and a preparation method thereof, belonging to the technical field of medicine. Background technique

[0002] Baohuoside I, chemical name: 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone-3-O-α-L-rhamnopyranoside, is a poly Hydroxyflavonoid monomer components. Pharmacological studies have shown that baohuoside I has anti-tumor and anti-osteoporosis effects. The chemical structure is shown in (I).

[0003]

[0004] However, the water solubility of baohuoside I is very low, it is difficult to administer by injection, and its oral absorption is also poor. At present, there is no report of baohuoside I phospholipid complex, let alone the report of baohuoside I-hydrogenated soybean phospholipid-dipalmitoyl lecithin complex. Contents of the invention

[0005] The object of the present invention is to provide a baohuoside I phospholipid complex and a preparation method thereof.

[0006] For the...

Examples

Embodiment 1

[0021] The molar ratio of baohuoside I and hydrogenated soybean lecithin is 1:1. Dissolve baohuoside I and hydrogenated soybean lecithin in absolute ethanol, stir at room temperature for 1 hour, evaporate in vacuum at 40°C, remove solvent, and dry in vacuum at 40°C , that is, Debao Huoside I Phospholipid Complex.

Embodiment 2

[0023] The molar ratio of baohuoside I and soybean lecithin is 1:2. Dissolve baohuoside I and soybean lecithin in absolute ethanol, stir at room temperature for 1 hour, evaporate in vacuum at 40°C, remove the solvent, and dry in vacuum at 40°C. Depot Huoside I Phospholipid Complex.

Embodiment 3

[0025] The molar ratio of baohuoside I and saturated lecithin is 1:1, dissolve baohuoside I and saturated lecithin in ethanol, stir at room temperature for 1 hour, evaporate in vacuum at 40°C, remove the solvent, and dry in vacuum at 40°C to obtain Baohuoside I Phospholipid Complex.