Medicinal composition of baohuoside I

A technology of baohuoside and composition, which is applied in the field of medicinal composition of baohuoside I, can solve the problems of low solubility and poor oral absorption of baohuoside I, and achieve the purpose of promoting intestinal transit and absorption, improving dissolution, inhibiting The effect of intestinal efflux

Inactive Publication Date: 2012-01-11
贾晓斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the low solubility of baohuoside I and poor oral absorption, there is currently no medicine for baohuoside I on the market

Method used

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  • Medicinal composition of baohuoside I
  • Medicinal composition of baohuoside I
  • Medicinal composition of baohuoside I

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The molar ratio of baohuoside I, soybean lecithin, and polyethylene glycol 1000 vitamin E succinate is 1:1:2. First, dissolve baohuoside I and soybean lecithin in absolute ethanol, stir at room temperature for 1 hour, and then add Polyethylene glycol 1000 vitamin E succinate, vacuum rotary evaporation at 40°C, removal of solvent, and vacuum drying at 40°C, namely the medicinal composition of diprophyllin I.

Embodiment 2

[0031] The molar ratio of baohuoside I, lecithin and polyethylene glycol 6000 is 1:1:2, first dissolve baohuoside I and lecithin in absolute ethanol, stir at room temperature for 1 hour, then add polyethylene glycol 6000 , spray-dried, that is, the medicinal composition of Dibaohuoside I.

Embodiment 3

[0033] Baohuoside I, Hydrogenated Lecithin, The molar ratio of HS-15 is 1:1:1. Dissolve baohuoside I and phospholipids in absolute ethanol, stir at room temperature for 1 hour, and then add HS-15, vacuum rotary evaporation at 40°C, remove the solvent, and vacuum dry at 40°C, namely the medicinal composition of dibaohuoside I.

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Abstract

The invention provides a medicinal composition of baohuoside I, which can increase the solubility of baohuoside I in water, and significantly improve the oral absorption of baohuoside I.

Description

technical field [0001] The invention relates to a medicinal composition of baohuoside I, which belongs to the technical field of medicine. Background technique [0002] Baohuoside I, chemical name: 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone-3-O-α-L-rhamnopyranoside, is a poly Hydroxyflavonoid monomer components. Pharmacological studies have shown that baohuoside I has anti-tumor and anti-osteoporosis effects. The chemical structure is shown in (I). [0003] [0004] However, due to the low solubility of baohuoside I and poor oral absorption, there is currently no medicine for baohuoside I on the market. Contents of the invention [0005] The purpose of the present invention is to provide a pharmaceutical composition for promoting the oral absorption of baohuoside I. [0006] For the purpose of the above invention, the present invention provides the following technical solutions: [0007] A medicinal composition of baohuoside I, characterized in that: in addition t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K47/24A61K47/34A61K47/14
Inventor 贾晓斌张振海孙娥谭晓斌金鑫陈玲玲
Owner 贾晓斌
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