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Antibiotic Lobophorin E and F, preparation methods and applications thereof in preparing antibacterial and antitumor drugs

A technology for antibiotics and streptomyces, applied in antitumor drugs, biochemical equipment and methods, antibacterial drugs, etc., can solve the problem of undetected antibacterial activity

Active Publication Date: 2012-01-18
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Claims
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Problems solved by technology

Lobophorin A and lobophorin B have been isolated from actinomycetes symbiotic with algae, and have shown anti-inflammatory activity, but no antibacterial activity has been detected (Jiang, Z.D., Jensen, P.R. & Fenical, W.Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium. Bioorg. Med. Chem. Lett., 1999, September, 2003-2006.)

Method used

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  • Antibiotic Lobophorin E and F, preparation methods and applications thereof in preparing antibacterial and antitumor drugs
  • Antibiotic Lobophorin E and F, preparation methods and applications thereof in preparing antibacterial and antitumor drugs
  • Antibiotic Lobophorin E and F, preparation methods and applications thereof in preparing antibacterial and antitumor drugs

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Embodiment 1

[0033] 1. Isolation and identification of Streptomyces sp.SCSIO 1127

[0034] The isolation of genomic DNA involved in the identification of Streptomyces sp.SCSIO 1127, PCR amplification of 16S rDNA, sequence alignment and establishment of phylogenetic tree are all references [Tian, ​​X.P., Zhi, X.Y., Qiu, Y.Q., Zhang, Y.Q., Tang, S.K., Xu, L.H., Zhang, S., Li, W.J. Sciscionella marina gen.nov., sp.nov., a marine actinomycete isolated from a sediment in the northern South China Sea. Int J Syst Evol Microbiol, 2009, 59(Pt 2): 222-228].

[0035] Source of the strain: Streptomyces sp.SCSIO 1127 was isolated from the seabed sediments at a depth of 1350 meters in the northern South my country Sea (E 111°54.693′, N08°56.003′).

[0036] Bacterial species identification: referring to the method in the above literature, the 16S rDNA of Streptomyces SCSIO 1127 was amplified by conventional PCR and sequenced. The sequence is shown in SEQ ID NO.1, and then submitted to GenBank to obtain ...

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Abstract

The invention discloses antibiotic Lobophorin E and F, preparation methods and applications thereof in preparing antibacterial and antitumor drugs. The Lobophorin E and F are obtained by separating from fermentation cultures of streptomyces SCSIO 1127; the Lobophorin E and F have antibacterial activities and can be used for preparing antibacterial drugs; the Lobophorin F has an antitumor activity and can be used for preparing antitumor drugs; and the structures of the antibiotic Lobophorin E and F are showed as a formula (I), wherein R is as the following for the lobophorin E, and R equals to H for the lobophorin F.

Description

Technical field: [0001] The invention belongs to the field of industrial microorganisms, and in particular relates to two new antibiotics Lobophorin E and F, a preparation method thereof, and an application in preparation of antibacterial and antitumor drugs. Background technique: [0002] Spirotetronate antibiotics are a class of natural products with antibacterial and antitumor activities, such as antlermicin, chlorothricin, kijanimicin, decatromicins, saccharocarcins, tetrocarcins and versipelostatins. Lobophorin A and lobophorin B have been isolated from actinomycetes symbiotic with algae, and have shown anti-inflammatory activity, but no antibacterial activity has been detected (Jiang, Z.D., Jensen, P.R. & Fenical, W.Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium. Bioorg. Med. Chem. Lett., 1999, 9, 2003-2006.). Recently, lobophorins C and lobophorin D were isolated from symbiotic Streptomyces spongiosa and showed selective ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C12P19/60C12N1/20A61K31/7048A61P31/04A61P35/00C12R1/465
Inventor 张长生李苏梅牛四文田新朋张海波张光涛张偲鞠建华
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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