Kits for survival and prognosis of glioblastoma related to SCOS3

A technology of glioblastoma and kit, which is applied in the field of disease diagnosis and can solve the problems that have not been significantly improved

Inactive Publication Date: 2012-01-25
江涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite advances in surgery, radiotherapy, and chemotherapy, this m

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  • Kits for survival and prognosis of glioblastoma related to SCOS3
  • Kits for survival and prognosis of glioblastoma related to SCOS3
  • Kits for survival and prognosis of glioblastoma related to SCOS3

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Embodiment Construction

[0018] The present invention will be described in further detail below in conjunction with embodiment.

[0019] 1. Patient information and source of specimens

[0020] A total of 100 cases of primary glioblastoma were enrolled in this study, all from the Glioma Treatment Center of Beijing Tiantan Hospital. All patients underwent surgical resection, radiotherapy, and alkylating agent chemotherapy from January 2006 to December 2008. The postoperative pathological diagnosis was primary glioblastoma (according to the 2007 WHO classification of central nervous system tumors).

[0021] Among all the patients, there were 56 males and 44 females; their age ranged from 17 to 70 years old, with an average of (43.8±14.5) years old. According to the overall survival (OS) of patients, 13 cases in the long survival group (OS > 18 months) and 20 cases in the short survival group (OS < 9 months) were randomly selected to complete the genome-wide DNA methylation microarray; the remaining 67 c...

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Abstract

The invention provides kits for the survival and the prognosis of glioblastoma related to SCOS3. The kits comprise a kit for extracting DNA from a tumor tissue sample of a patient with primary glioblastoma, an optional instruction manual for the DNA extracting kit, a kit for analyzing the methylation level of gene SOCS3 in the extracted DNA and an optional instruction manual for the kit for analyzing the methylation level of the gene SOCS3. The invention also provides a molecular marker SOCS3 gene for the survival and the prognosis of glioblastoma.

Description

technical field [0001] The invention relates to the field of disease diagnosis, in particular to a kit for survival and prognosis of glioblastoma. Background technique [0002] Glioblastoma (glioblastoma multiforme, GBM) is the most common primary brain tumor in adults, and its survival prognosis is extremely poor, with a median survival time of about 12-14 months. Despite advances in surgery, radiotherapy, and chemotherapy, this measure has not improved significantly over the past 20 years [1,2]. Esteller's research group [3] first reported the relationship between the hypermethylation of MGMT gene and the sensitivity to alkylating agent treatment and survival prognosis in malignant glioma. The methylation status of MGMT gene is the first molecular marker that can be used to evaluate the clinical prognosis of malignant glioma. MGMT gene silencing is related to the efficacy of temozolomide (TMZ). If there is hypermethylation of MGMT gene in GBM patients, the 2-year surviva...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/12
Inventor 江涛张伟
Owner 江涛
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