Medical silicon rubber with modified hydrophilic structure on surface, and preparation and application of medical silicon rubber

A hydrophilic structure, silicone rubber technology, used in medical science, surgery, etc., can solve the problems of not reducing the modification effect, reducing cost, high price, etc., reducing adsorption and cell adhesion, improving biocompatibility, The effect of prolonging the service life

Active Publication Date: 2012-10-31
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Introduce some hydrophilic polymer substances on the surface of implant materials, such as polyethylene oxide and its derivatives [Chen H, Zhang Z, ChenY, et al. Protein repellant silicone surfaces by covalent immobilization of poly(ethylene oxide ) (silicone rubber surface with anti-protein properties covalently treated with polyethylene oxide) biomaterials, 2005, 26(15): 2391-2399], polyethylene oxide and its derivatives have a large number of hydrophilic groups group, which can improve the strong hydrophobicity of the surface of silicone rubber, but because polyethylene oxide and its derivatives are relatively expensive, the present invention utilizes polyethylene glycol methyl ether acrylate as a surface-modified hydrophilic The price is relatively low, and it also significantly improves the hydrophilicity of the surface of silicone rubber. This method reduces the cost and does not reduce the modification effect

Method used

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  • Medical silicon rubber with modified hydrophilic structure on surface, and preparation and application of medical silicon rubber
  • Medical silicon rubber with modified hydrophilic structure on surface, and preparation and application of medical silicon rubber
  • Medical silicon rubber with modified hydrophilic structure on surface, and preparation and application of medical silicon rubber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Measure 4.5mL of polymethylhydrogensiloxane solution and 7.5mL of anhydrous methanol solution, and magnetically stir to form a mixed solution. Place a medical silicone rubber block with a size of 4mm×2.5mm×0.7mm in the mixed solution of polymethylhydrogensiloxane and anhydrous methanol, then add 0.04mL trifluoromethanesulfonic acid, seal the reaction device, and The reaction was stirred magnetically for 75 minutes at room temperature. After the reaction was completed, the medical silicone rubber sample was thoroughly washed with an appropriate amount of n-hexane solution and anhydrous methanol solution, and dried in vacuum for 1 day to obtain a medical silicone rubber sample with Si-H active groups on the surface.

[0026] (2) Measure 11.38 mL of polyethylene glycol methyl ether acrylate solution with a molecular weight of 480 kD and 3.63 mL of isopropanol solution, and stir magnetically to form a mixed solution. Place the surface-functionalized medical silicone ru...

Embodiment 2

[0029] The raw materials and preparation method are similar to Example 1, except that the amount of polymethylhydrogensiloxane and anhydrous methanol is changed from 4.5mL and 7.5mL to 5mL and 10mL, and the dynamic contact of the prepared surface hydrophilic medical silicone rubber The angle is 110.6°.

Embodiment 3

[0031] The raw materials and preparation method are similar to those in Example 2, except that polymethylhydrogensiloxane, the amount of anhydrous methanol is changed from 5mL and 10mL to 5mL and 15mL, and the dynamic contact angle of the prepared surface hydrophilic medical silicone rubber is 112.4°.

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Abstract

The invention discloses medical silicon rubber with a modified hydrophilic structure on the surface, and preparation and application of the medical silicon rubber. The structure of the silicon rubber with surface hydrophilicity is a polydimethylsiloxane-poly(ethylene glycol) methyl ether acrylate graft copolymer on which a large number of hydrophilic ester bonds are carried. A preparation method comprises the following steps of: guiding a reactive functional group, namely an Si-h group onto the surface of medical silicon rubber in a mixed solution of poly(methyl hydrogen siloxane), absolute methanol and trifluoromethanesulfonic acid, and grafting poly(ethylene glycol) methyl ether acrylate onto the surface of the medical silicon rubber through hydrosilylation reaction under the action of a platinum catalyst. The preparation method for the medical silicon rubber with surface hydrophilicity is simple, the source of raw materials is rich, and the strong hydrophobicity of the surface of silicon rubber is well improved, so the medical silicon rubber meets the requirement of surface hydrophilicity of a glaucoma drainage device.

Description

technical field [0001] The invention relates to a medical silicone rubber with a modified hydrophilic structure on the surface, its preparation and application, and belongs to the medical silicone rubber material modification technology. Background technique [0002] Glaucoma is the second most irreversible blinding eye disease in the world. my country is the country with the largest population of glaucoma in the world, and glaucoma is also one of the main blinding eye diseases in my country. At present, glaucoma valve implantation is a relatively advanced method for treating various glaucoma in the world, especially for the treatment of refractory glaucoma. The main principle of glaucoma valve implantation is to implant a drainage device in the patient's eye to drain out the aqueous humor and reduce the intraocular pressure [DeCroos FC, Ahmad S, Kondo Y, et al. Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve (The effect of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08L83/04A61L31/06A61L31/14
Inventor 尹玉姬张琳
Owner TIANJIN UNIV
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