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Soap-free preparation method for biodegradable polymer nano particles

A technology for degrading polymers and nanoparticles, applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve problems such as difficult to completely remove, complex and cumbersome post-processing process, etc., achieve good universality, and eliminate post-processing process, the effect of broadening the scope of application

Active Publication Date: 2014-03-26
武汉天时维璟微生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the preparation of the emulsion method, surfactants are usually added to prevent the emulsion droplets from merging. These surfactants complicate the post-processing process and are often difficult to completely remove; and studies have shown that a small amount of residual surfactants will directly affect cell behavior. and drug release, which limits the application of this method in biomedicine

Method used

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  • Soap-free preparation method for biodegradable polymer nano particles
  • Soap-free preparation method for biodegradable polymer nano particles
  • Soap-free preparation method for biodegradable polymer nano particles

Examples

Experimental program
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Effect test

Embodiment 1

[0023]Example 1: Dissolve 0.8 mg of PDLLA (molecular weight: 10,000) in 1 mL of co-solvent THF, and magnetically stir for 1 to 10 minutes until fully dissolved; then, under stirring, use a syringe pump to inject the above solution at a speed of 2 mL / h Add 2 mL of deionized water to obtain a mixed solution. Next, THF was gradually evaporated at room temperature. After THF is completely volatilized, PDLLA biodegradable polymer nanoparticles are obtained, see figure 1 . The average particle diameter is 775.9 nm, and the PDI is 0.141.

Embodiment 2

[0024] Example 2: Dissolve 0.2 mg of PDLLA (molecular weight: 50,000) in 1 mL of co-solvent THF, and magnetically stir for 1 to 10 minutes until fully dissolved; then, under stirring, use a syringe pump to inject the above solution at a speed of 60 mL / h Add 1 mL of deionized water to obtain a mixed solution. Next, THF was gradually evaporated at room temperature. After THF is completely volatilized, PDLLA biodegradable polymer nanoparticles are obtained, see figure 2 . The average particle diameter is 169.7 nm, and the PDI is 0.012.

Embodiment 3

[0025] Example 3: Dissolve 0.8 mg of PDLLA (molecular weight: 50,000) in 1 mL of co-solvent THF, and magnetically stir for 1 to 10 minutes until fully dissolved; then, under stirring, use a syringe pump to inject the above solution at a speed of 160 mL / h Add 1 mL of deionized water to obtain a mixed solution. Next, THF was gradually evaporated at room temperature. After THF is completely volatilized, PDLLA biodegradable polymer nanoparticles are obtained, see image 3 a. The average particle diameter is 118.8nm, and the PDI is 0.046.

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Abstract

The invention provides a soap-free preparation method for biodegradable polymer nano particles. The method comprises the following main steps of: fully dissolving a biodegradable polymer into a good solvent to obtain a uniformly dispersed biodegradable polymer solution; and slowly injecting a precipitant into the biodegradable polymer solution by using an injection pump under a uniform magnetic stirring condition, and standing the mixed solution at room temperature to volatilize the good solvent. The mixed solution is gradually turbid from clear and transparent together with volatilization of the good solvent. The mixed solution is stood for two days, and biodegradable polymer nano particle dispersion is obtained after the good solvent is completely volatilized. By the method, the size of the biodegradable polymer nano particles can be effectively controlled according to the actual requirement, and the single-dispersion biodegradable polymer nano particles of different size ranges are prepared. Compared with other emulsion preparation methods, the method has the advantage of avoiding complex and fussy post treatment processes because any surfactant is not required to be added in preparation.

Description

technical field [0001] The invention belongs to a method for preparing biodegradable polymer nanoparticles, in particular to a method for preparing biodegradable polymer nanoparticles that are monodisperse, adjustable in size and do not contain surfactants. Background technique [0002] Polymer nanoparticles have the advantages of surface modification and strong designability, and have important applications in the fields of optics, electronics, biotechnology, especially drug delivery and release. Many drugs need to circulate in the human body for a long time and release slowly at the lesion site to reduce side effects and administration times; at the same time, some drugs cannot be used directly due to their strong side effects or the efficacy of direct use is not ideal. Due to the excellent biocompatibility and degradability of biodegradable polymers, it has been found that the use of such polymers as drug carriers can smoothly distribute insoluble complex drugs in the les...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/14C08L67/04A61K47/34
Inventor 朱锦涛梁锐晶
Owner 武汉天时维璟微生物科技有限公司