Repaglinide orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses a repaglinide orally disintegrating tablet and preparation method of the tablet. The repaglinide orally disintegrating tablet has a good taste, and disintegrates rapidly in water so that the repaglinide can be dissolved rapidly, and thus the dissolution and bioavailability of the drug can be improved greatly. The tablet is suitable for administration by senile patients and patients with difficulty in swallowing.

Description

technical field [0001] The invention relates to an orally disintegrating tablet of a medicine for treating diabetes and a preparation method thereof, in particular to an orally disintegrating repaglinide tablet and a preparation method thereof. Background technique The incidence of diabetes is increasing year by year. China has become the hardest-hit area of ​​the disease, and the number of diabetic patients ranks second in the world, while Type 2 diabetes accounts for almost 100%. Some patients with type 2 diabetes mainly have insulin resistance, but compared with the hyperglycemia of patients, insulin secretion is still relatively insufficient; some patients mainly have insulin secretion defects. Repaglinide can be combined with special sites to close the ATP-dependent potassium channel on the islet β-cell membrane, open the calcium channel, increase the calcium influx, and induce the islet to secrete insulin. It is inconvenient to take tablets or capsules for so...

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to solve the problem of repaglinide's sandy feeling and its disintegration rate, and provide a repaglinide orally disintegrating tablet and its preparation method

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