Medical composition containing amorphous atorvastatin calcium

A technology of atorvastatin calcium and its composition, which is applied in the field of pharmaceutical compositions containing amorphous atorvastatin calcium, can solve the problems of poor stability, slow dissolution, delayed disintegration, etc., achieve complete dissolution and improve stability , fast disintegration effect
CN101766593AInactive Publication Date: 2010-07-07BEIJING D VENTUREPHARM TECH DEV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING D VENTUREPHARM TECH DEV
Publication Date
2010-07-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a medical composition containing amorphous atorvastatin calcium and a preparation method thereof. By adopting the medical composition, the stability of the medicines is obviously improved, the disintegration speed fastened and the dissolution improved. The medical composition is used for treating high cholesterin lipidemia, can reduce administration dosage, avoids great quantity of medication, enables the blood drug concentration of patients to be smooth and simultaneously increases compliance.
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Description

technical field

[0001] The invention discloses a pharmaceutical composition for treating hypercholesterolemia, in particular to a pharmaceutical composition containing amorphous atorvastatin calcium. Background technique

[0002] The chemical name of atorvastatin is: [R-(R,R)]-2-(4-fluorophenyl)-β,β-dihydroxy-5-(1-methylethyl)-3-benzene Calcium-4-[(aniline)carbonyl]-1hydro-pyrrole-1-heptanoate trihydrate. This product is a selective and competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-C) synthesized in recent years 0 A) Reductase inhibitor, the lipid-lowering effect is higher than other HMG-C 0 A reductase inhibitor. The clinical use of atorvastatin calcium has definite curative effect and remarkable effect, but because atorvastatin calcium has a bitter taste and is very slightly soluble in water, it is very sensitive to light, temperature and humidity. Therefore, there are problems such as poor stability, delayed disintegration, and slow dissolution in clinical pr...

Claims

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