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Medical composition containing amorphous atorvastatin calcium

A technology of atorvastatin calcium and its composition, which is applied in the field of pharmaceutical compositions containing amorphous atorvastatin calcium, can solve the problems of poor stability, slow dissolution, delayed disintegration, etc., achieve complete dissolution and improve stability , fast disintegration effect

Inactive Publication Date: 2010-07-07
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in clinical practice, there are problems such as poor stability, delayed disintegration, and slow dissolution.

Method used

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  • Medical composition containing amorphous atorvastatin calcium
  • Medical composition containing amorphous atorvastatin calcium
  • Medical composition containing amorphous atorvastatin calcium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Tablets made of HPMC as binder

[0015]

[0016] Preparation process: Weigh amorphous atorvastatin calcium, lactose, microcrystalline cellulose, croscarmellose sodium, and colloidal silicon dioxide according to the prescription, use HPMC as a binder, and wet granulate with 30 mesh. Dry at 60°C. The granules are granulated with 24 meshes, the water content is measured, after adding magnesium stearate, the tablets are compressed at 60-80N.

Embodiment 2

[0018] Tablets made of starch slurry as binder

[0019]

[0020]

[0021] Preparation process: Weigh amorphous atorvastatin calcium, lactose, microcrystalline cellulose, croscarmellose sodium, and Tween 80 according to the prescription amount, use starch slurry as a binder, and wet granulate with a size of 30 mesh. Dry at 60°C. The granules are granulated with 24 meshes, the water content is measured, after adding magnesium stearate, the tablets are compressed at 60-80N.

Embodiment 3

[0023] Tablets made of starch slurry as binder

[0024]

[0025] Preparation process: Weigh amorphous atorvastatin calcium, lactose, microcrystalline cellulose, croscarmellose sodium, and sodium lauryl sulfate according to the prescription, use starch slurry as a binder, and wet 30 mesh Granulated by law and dried at 60°C. The granules are granulated with 24 meshes, the water content is measured, after adding magnesium stearate, the tablets are compressed at 60-80N.

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Abstract

The invention discloses a medical composition containing amorphous atorvastatin calcium and a preparation method thereof. By adopting the medical composition, the stability of the medicines is obviously improved, the disintegration speed fastened and the dissolution improved. The medical composition is used for treating high cholesterin lipidemia, can reduce administration dosage, avoids great quantity of medication, enables the blood drug concentration of patients to be smooth and simultaneously increases compliance.

Description

technical field [0001] The invention discloses a pharmaceutical composition for treating hypercholesterolemia, in particular to a pharmaceutical composition containing amorphous atorvastatin calcium. Background technique [0002] The chemical name of atorvastatin is: [R-(R,R)]-2-(4-fluorophenyl)-β,β-dihydroxy-5-(1-methylethyl)-3-benzene Calcium-4-[(aniline)carbonyl]-1hydro-pyrrole-1-heptanoate trihydrate. This product is a selective and competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-C) synthesized in recent years 0 A) Reductase inhibitor, the lipid-lowering effect is higher than other HMG-C 0 A reductase inhibitor. The clinical use of atorvastatin calcium has definite curative effect and remarkable effect, but because atorvastatin calcium has a bitter taste and is very slightly soluble in water, it is very sensitive to light, temperature and humidity. Therefore, there are problems such as poor stability, delayed disintegration, and slow dissolution in clinical pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61P3/06
Inventor 蔡巍
Owner BEIJING D VENTUREPHARM TECH DEV
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