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Application of Chinese medicinal composition to preparation of anti-myocardial cell apoptosis and/or anti-myocardial cell apoptosis related disease drug

A technique for cardiomyocyte apoptosis and composition, which is applied in the field of traditional Chinese medicine and can solve the problems of decreasing the number and function of cardiomyocytes, aggravating myocardial ischemia damage, etc.

Active Publication Date: 2012-09-19
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once the apoptosis program is started, quite a few of the originally repairable cardiomyocytes will also go to the death process, resulting in a decline in the number and function of functional cardiomyocytes, and aggravating myocardial ischemia injury.

Method used

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  • Application of Chinese medicinal composition to preparation of anti-myocardial cell apoptosis and/or anti-myocardial cell apoptosis related disease drug
  • Application of Chinese medicinal composition to preparation of anti-myocardial cell apoptosis and/or anti-myocardial cell apoptosis related disease drug
  • Application of Chinese medicinal composition to preparation of anti-myocardial cell apoptosis and/or anti-myocardial cell apoptosis related disease drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Step 1. Take the following medicinal materials: Rehmannia glutinosa 100g, Caulis Spatholobus 100g, Ophiopogon japonicus 60g, Licorice 60g, Polygonum multiflorum 60g, Donkey-hide gelatin 60g, Schisandra 60g, Codonopsis 60g, Tortoise shell (made with vinegar) 40g, Jujube 40g, Guizhi 20g;

[0086] Step 2. Add Caulis Spatholobus, Codonopsis pilosula, Schisandra chinensis, jujube, and tortoise shell to decoction twice, 3 hours each time, combine the filtrate, filter, and condense into a thick paste;

[0087] Step 3. The remaining medicinal materials and 6 herbs are divided into fine powders, and the thick paste obtained in step 1 is added, uniformly dried, divided into fine powders, sieved, pilled with water, dried, and coated to obtain pills.

Embodiment 2

[0089] The same method as in Example 1, except that the composition of medicinal materials is different: 200g of rehmannia root, 200g of Caulis Spatholobus, 138g of Radix Ophiopogon japonicus, 138g of Radix Glycyrrhizae, 138g of Radix Polygoni Multiflori, 138g of donkey-hide gelatin, 138g of Schisandra chinensis, 138g of Codonopsis pilosula, 100g of tortoise shell (made from vinegar), Jujube 100g, Guizhi 40g.

Embodiment 3

[0091] The method is the same as that of Example 1, except that the composition of the medicinal materials is different: 20g of rehmannia glutinosa, 20g of Caulis Spatholobus, 20g of Ophiopogon japonicus, 20g of licorice, 20g of Polygonum multiflorum, 20g of donkey-hide gelatin, 20g of Schisandra chinensis, 20g of Codonopsis pilosula, 20g of tortoise shell (made from vinegar), Jujube 20g, Guizhi 10g.

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Abstract

The invention discloses an application of a Chinese medicinal composition to preparation of an anti-myocardial cell apoptosis and / or anti-myocardial cell apoptosis related disease drug. The Chinese medicinal composition is prepared by, by weight, 1-10 parts of rehmannia roots, 1-10 parts of caulis spatholobi, 1-7 parts of dwarf lilyturf tuber, 1-7 parts of liquorice roots, 1-7 parts of prepared fleeceflower roots, 1-7 parts of donkey-hide gelatin, 1-7 parts of Chinese magnoliavine fruits, 1-7 parts of pilose asiabell roots, 1-5 parts of tortoise shells, 1-5 parts of Chinese dates and 0,1-2 parts of cassia twig.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of medicines for resisting cardiomyocyte apoptosis and / or anti-cardiomyocyte apoptosis-related diseases. Background technique [0002] Tongmai Yangxin Pill is a Chinese patent medicine for treating ischemic heart disease. It is composed of Shengmaisan and Zhigancao Decoction. Tongmai Yangxin Pills is aimed at the pathological state of thoracic obstruction with deficiency and superficiality, and rehmannia glutinosa nourishes yin and nourishes blood as the king. "Famous Doctors Bielu" says that rehmannia "replenishes the deficiency of internal injuries of the five internal organs, unblocks the blood vessels, and replenishes energy." In the prescription, roasted licorice, Codonopsis pilosula, and jujube benefit qi and strengthen the spleen; rehmannia glutinosa, donkey-hide gelatin, and Ophiop...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P9/00A61P9/10A61K35/36A61K35/56A61K35/586
Inventor 王磊
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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