Preparation method for oral nursing solution for preventing oral mucositis caused by chemotherapy

A technology for oral care solution and oral mucositis, applied in the field of traditional Chinese medicine, can solve problems such as low efficiency, and achieve the effects of reducing adverse reactions and reducing impurities in medicinal residues

Inactive Publication Date: 2012-10-03
张秀香
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is: the total effective rate is low, probably maintained at about 60%

Method used

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  • Preparation method for oral nursing solution for preventing oral mucositis caused by chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1, the weight ratio of raw materials: white horse bone 6g, Ligustrum lucidum 8g, fig leaf 8g, habitat 6g, Scrophulariaceae 6g, Radix Ophiopogon japonicus 8g, Adenophora 6g, Anemarrhena 8g, Sarcorrhizae 3g. Its preparation method comprises the following steps:

[0027] (1) Mix the white horse bone, privet lucidum, fig leaves, and sarcophagus, add 3 times the weight of water, collect the distillate by steam distillation, redistill the distillate, and obtain the rectified liquid for later use;

[0028] (2) Add the distilled medicinal residues of raw materials to Shengdi, Scrophulariae, Ophiopogon japonicus, Adenophora, Anemarrhena, add 4 times the weight of water, boil and decoct twice, each time for 1 hour, filter, and combine the two filtrates;

[0029] (3) The filtrate is centrifuged (300r / min) for 10min with a centrifuge, the supernatant is taken, added to the rectified liquid, mixed evenly, and ultrafiltered after adding water for injection;

[0030] (4) The ...

Embodiment 2

[0031] Example 2, the weight ratio of raw materials: white horse bone 10g, Ligustrum lucidum 15g, fig leaf 15g, habitat 10g, Scrophulariaceae 10g, Ophiopogon japonicus 15g, Adenophora 10g, Anemarrhena 15g, Sarcodon 6g. Its preparation method comprises the following steps:

[0032] (1) Mix the white horse bone, privet citrus lucidum, fig leaf, and sarcophagus, add 6 times the weight of water, collect the distillate by steam distillation, redistill the distillate, and obtain the rectified liquid for later use;

[0033] (2) Add the distilled raw drug residues to Shengdi, Scrophulariae, Ophiopogon japonicus, Adenophora, Anemarrhena, add 6 times the weight of water, boil and decoct twice, each time for 2 hours, filter, and combine the two filtrates;

[0034] (3) The filtrate was centrifuged with a centrifuge (600r / min) for 5 minutes, the supernatant was taken, added to the rectified liquid, mixed evenly, and ultrafiltered after adding water for injection;

[0035] (4) The ultrafil...

Embodiment 3

[0036] Example 3, the weight ratio of raw materials: white horse bone 8g, Ligustrum lucidum 10g, fig leaf 10g, habitat 8g, Scrophulariaceae 8g, Ophiopogon japonicus 10g, Radix Adenophora 8g, Anemarrhena 10g, Sargassum 5g. Its preparation method comprises the following steps:

[0037] (1) Mix the white horse bone, privet lucidum, fig leaves, and sarcophagus, add 5 times the weight of water, collect the distillate by steam distillation, redistill the distillate, and obtain the rectified liquid for later use;

[0038] (2) Add the distilled medicinal residues of raw materials into Shengdi, Scrophulariae Radix, Ophiopogon japonicus, Radix Arrhea, Anemarrhena, add 5 times the weight of water, boil and decoct twice, each time for 1.5 hours, filter, and combine the two filtrates;

[0039] (3) The filtrate was centrifuged with a centrifuge (300r / min) for 15 minutes, the supernatant was taken, added to the rectified liquid, mixed evenly, added with water for injection, and ultrafiltered...

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Abstract

The invention discloses a preparation method for oral nursing solution for preventing the oral mucositis caused by chemotherapy, for solving a problem of prevention for the oral mucositis caused by chemotherapy. The raw materials of the oral nursing solution comprise serissa serissoides, fructus ligustri lucidi, ficus virens leaves, sarcandra glabra, radix rehmanniae, radix scrophulariae, radix ophiopogonis, radix adenophorae and rhizoma anemarrhenae; and the preparation method is characterized by comprising the following steps of: (1) distilling the serissa serissoides, the fructus ligustri lucidi, the ficus virens leaves and the sarcandra glabra with steam to obtain a distillate; (2) adding the radix rehmanniae, the radix scrophulariae, the radix ophiopogonis, the radix adenophorae and the rhizoma anemarrhenae in the dregs of the distilled raw material medicines, and decocting with water to obtain a filtrate; (3) centrifuging the filtrate to obtain the supernatant, adding the distillate, adding water for injection, and then performing ultrafiltration; and (4) filling, sterilizing and packaging the ultrafiltrate. Clinical experiments prove that the oral nursing solution prepared by the method disclosed by the invention has characteristics of good curative effect and high safety for preventing the oral mucositis caused by chemotherapy, and is worthy of clinical application andpopularization.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing an oral care solution for preventing oral mucositis caused by chemotherapy. Background technique [0002] Oral mucositis (OM) refers to the inflammatory and ulcerative reaction of the oral cavity. It is one of the more common and serious complications of chemotherapy in patients with malignant tumors. The incidence of stomatitis in patients with conventional chemotherapy is as high as 40%. The incidence of stomatitis is higher in patients with head and neck tumors and combined chemotherapy. The main symptoms are local pain and loss of taste, especially after eating, talking, and encountering cold, hot, sour, sweet and other stimuli. It directly affects the patient's eating and brings great misery to the patient. At the same time, treatment will be delayed and the dose of chemotherapy drugs will be reduced, which will adversely affect the progn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P1/02
Inventor 张秀香
Owner 张秀香
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