Normal-tension glaucoma susceptibility gene and method for using the same

A technology for normal intraocular pressure and glaucoma, applied in disease diagnosis, biochemical equipment and methods, material inspection products, etc., can solve problems such as unclear correlation

Inactive Publication Date: 2012-11-07
MENICON CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Concentrated efforts have been carried out on the analysis of myocilin (non-patent literature 1-15) and optineurin (non-patent literature 16-30), optic atrophy 1 (non-patent literature 31-41) genes that are highly suspected to be related to glaucoma, but NTG The relevance of
In addition, analysis of candidate genes was performed, but only relevant implications

Method used

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  • Normal-tension glaucoma susceptibility gene and method for using the same
  • Normal-tension glaucoma susceptibility gene and method for using the same
  • Normal-tension glaucoma susceptibility gene and method for using the same

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Experimental program
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Effect test

Embodiment 1

[0107] With regard to the samples of NTG patients and healthy people, under the permission of the Yokohama City University School of Medicine and the Ethics Committee, the center of this facility collects blood leukocytes from NTG patients who meet strict criteria such as age, intraocular pressure, and refractive error.

[0108] The diagnostic criteria of NTG are based on the criteria of the Japanese Glaucoma Society.

[0109] As primary (preliminary identification), 305 patients and 355 healthy people were selected as objects, and 53 gene regions were screened out. As follow-up replication (repeat identification), 214 different patients and 257 healthy individuals were selected as subjects, and 4 SNPs that are expected to be highly effective were identified. These four genes are shown in the table, and the respective results of primary and replication and values ​​calculated for all samples (overall) are shown.

[0110] Genotyping was carried out using the GeneChip Human Map...

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Abstract

Provided are a normal-tension glaucoma susceptibility gene and a method for using the same. Comprehensive analysis and comparison of single-nucleotide polymorphism on the entire genome of a large number of normal-tension glaucoma patients and normal subjects led to the discovery of differences in polymorphism sites, and it was discovered that of these different polymorphism sites, the polymorphism sites of single-nucleotide polymorphism international No. rs3213787, No. rs735860, No. rs4412249, and No. rs2763979 are effective in the diagnosis of normal-tension glaucoma.

Description

technical field [0001] The invention relates to a normal tension glaucoma disease susceptibility gene and its application. Background technique [0002] Glaucoma is a progressive, intractable disease that damages the optic nerve when the intraocular pressure rises above the healthy intraocular pressure that can maintain normal visual function. If the disease is left untreated, the narrowing of the visual field will increase, and sometimes blindness will be caused. Although this disease is currently the number one cause of blindness in Japan, the cause is still unclear, and there is no accurate diagnosis method or effective treatment method. and methods of prevention. The most common among Japanese is normal tension glaucoma (NTG) in which glaucoma occurs although the intraocular pressure is within the normal range, and its frequency of occurrence is about 4% in people over 40 years old. NTG is difficult to detect in intraocular pressure examination because the intraocular ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/09G01N33/53G01N37/00
CPCC12Q2600/156C12Q2600/172G01N2800/168C12Q1/6883C12Q1/6834G01N33/5308
Inventor 水木信久
Owner MENICON CO LTD
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