Preparation method and quality control method for schefflera kwangsiensis general flavone extract

A quality control method and Hantao leaf technology are applied in the field of preparation of Hantao leaf total flavonoid extract, which can solve the problem that process parameters, process conditions and process technology are unreasonable, cannot be well adapted to industrial production needs, and product quality is difficult to achieve. Effectively control and other issues to achieve the effect of shortening the production cycle, short preparation time, and quality control

Inactive Publication Date: 2012-12-26
GUANGXI JINHAITANG PHARMA
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Problems solved by technology

[0003] The national pharmacopoeia standard of Chinese peach leaf (2010 edition one) records the preparation and content determination method of the total flavonoid extract, but the process parameters, process conditions and process technology of the preparation method are unreasonable, the extraction yield is low, and the content determination method Determinatio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 (preparation of total flavonoids extract from Chinese peach leaves):

[0018] Take Han peach leaves and add 8 times the weight of the volume concentration to soak in 60% ethanol for 0.5 hours, reflux extraction twice, 2 hours each time, filter, combine the filtrates, concentrate under reduced pressure (temperature is 85 °C) to a relative density of 1.10 ( 60 ℃) extract, that is.

Embodiment 2

[0019] Example 2 (preparation of total flavonoids extract from Chinese peach leaves):

[0020] Take Chinese peach leaves and add 9 times the weight of the volume concentration to 70% ethanol to soak for 0.5 hours, reflux extraction twice, the first time is 2.5 hours, the second time is 1.5 hours, filter, combine the filtrates, concentrate under reduced pressure (temperature is 75 °C ) to an extract with a relative density of 1.10 (60°C).

Embodiment 3

[0021] Example 3 (preparation of total flavonoids extract from Chinese peach leaves):

[0022] Take Han peach leaves and add 9 times the weight of the volume concentration to 60% ethanol, soak for 0.5 hours, reflux extraction 3 times, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure (temperature is 80 ℃) to a relative density of 1.20 ( 60 ℃) extract, that is.

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PUM

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Abstract

The invention discloses a preparation method and a quality control method for schefflera kwangsiensis general flavone extract. The preparation technology for the extract comprises the steps as follows: soaking a schefflera kwangsiensis medicinal material for 0.5 h by adding 8 to 10 times of ethanol by weight, wherein the volume concentration of the ethanol is from 60% to 80%; refluxing and extracting for 2 to 3 times with each time of 1 to 3 h; filtering and mixing filtrate; and decompressing and concentrating the filtrate at the temperature of 75 to 85 DEG.C to the temperature of 60 DEG.C, so as to obtain the extract with relative density of 1.10 to 1.30. The product quality control method mainly adopts a high performance liquid chromatography to detect the content of rutin. The preparation technology provided by the invention has the advantages of stable process parameter, process condition and process technology, high rutin extracting yield and strong industrial applicability. The quality control method provided by the invention has the advantages of high degree of separation, good linear relation, convenience, rapidness, accuracy and stability. Therefore, the quality control method meets the requirements of industrial production, and effectively controls the quality of the schefflera kwangsiensis general flavone extract and a preparation thereof.

Description

technical field [0001] The invention relates to a preparation method of Chinese peach leaf total flavonoid extract and a product quality control method. Background technique [0002] Chinese peach leaves are the tender stems and leaves of Schefflera kwangsiensis Merr. Ex L, a plant of the genus Schefflera in Araliaceae. Widely distributed in Guangxi, Guangdong, Fujian and other areas south of the Yangtze River, the main chemical and active ingredients of Chinese peach leaves are total flavonoids, mainly containing quercetin and rutin. Oral preparations such as tablets, capsules, dripping pills, and granules made from the total flavonoid extract have quick onset and long-lasting effects. [0003] The national pharmacopoeia standard of Chinese peach leaf (2010 edition one) records the preparation and content determination method of the total flavonoid extract, but the process parameters, process conditions and process technology of the preparation method are unreasonable, the...

Claims

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Application Information

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IPC IPC(8): A61K36/25G01N30/02A61K127/00A61K135/00
Inventor 马健雄邓福胜张平吉罗宇
Owner GUANGXI JINHAITANG PHARMA
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