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A technology of nano-silver and nano-silver ions, which is applied in the direction of antifungal agent, antibacterial drug, aerosol delivery, etc.
Inactive Publication Date: 2013-01-09
HUAXIU SCI TECH +1
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[0004]1. Silver ions attack the -SH group in the metabolic enzymes inside the bacteria, which inactivates the metabolic enzymes of the bacteria and hinders the normal metabolism of the bacteria;
[0005]2. Silver ions react with the peptidoglycan exposed on the bacterial cell wall, making it impossible to transfer energy into the cell, hindering the normal physiological activities of the bacteria;
However, the stability of silver nitrate and long-term use of silver nitrate solution may cause skin irritation such as local erythema, hyperemia, and burning sensation, which limit the use of silver nitrate solution.
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[0026] Example 1. Take 120ml of nano-silver colloid, add 20ml of glycerin, 10ml of polyethylene glycol-400, appropriate amount of foaming agent, add deionized water to 1000ml, stir evenly, and then 1000ml of gynecological antibacterial spray can be prepared .
[0027] Embodiment 2. Take 143 ml of 210 μg / ml nano-silver colloid, 5 ml of Tween-80, 20 ml of 3.55 mol / L acetic acid solution, 20.3~24.8 g of trisodium citrate, appropriate amount of correctives, and set it with deionized water. Make up to 1000ml, shake well to get 1000ml of 30 μg / ml nano-silver solution. It can be used in nasal antibacterial spray.
Embodiment 1
[0028] Antibacterial test is carried out to embodiment 1,2
[0029] The 24h slant culture of the test bacteria was washed with PBS and diluted to a bacterial suspension with a concentration of 3×106 cfu / ml. Take 1 tube of 5ml of medicinal solution or blank matrix; take 0.1ml of the above-mentioned bacterial suspension and put it in the tube, start timing, act for 2min, 5min, 10min, 20min, pipette 0.5ml of the solution in the medicinal solution tube with a sterile pipette and put it into the tube containing In a test tube of 4.5ml PBS, mix well, act for 10 minutes, dilute appropriately, draw 1ml respectively and place in two plates, use nutrient agar medium cooled to 60°C (for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa) Or pour 20ml of Sabouraud agar medium (for Candida albicans), rotate the plate to make it fully uniform, turn over the plate after the agar solidifies, and incubate at 37°C for 48h. Count live bacteria. Use double distilled water instead o...
example 1
[0034] Example 1 20 μg / ml has 100% antibacterial rate against Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa for 2 minutes, 5 minutes, 10 minutes and 20 minutes.
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Abstract
The invention relates to a nanosilver bacteriostatic spray, wherein the components of the nanosilver bacteriostatic spray are as follows: a nanosilver ion colloidal solution, a stabilizing agent, an osmotic pressure regulator, a pH regulator, a humectant and a foaming agent. The nanosilver bacteriostatic spray provided by the invention takes nitrate-free silver ion colloid as a bacteriostatic component and has the advantages of being good in bacteriostatic effect, stable in quality, fast in bacteriostasis and free from irritation and the like, and has stronger inbibitional effects on escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, haemophilus influenza, pneumococcus and group B streptococcus and the like, so that the nanosilver bacteriostatic spray is suitable for the diseases with bacterial and fungal infection in the nasal cavities and female vaginas and the like. According to the nanosilver bacteriostatic spray, the preparation method is simple, and the nanosilver bacteriostatic spray is convenient to use and significant in efficacy.
Description
technical field [0001] The invention relates to an antibacterial spray, in particular to a nano silver antibacterial spray. Background technique [0002] As the latest generation of natural antibacterial agent, nano-silver has the characteristics of broad-spectrum antibacterial, no drug resistance, safety and non-toxicity. The corresponding nano-silver products developed by researchers at home and abroad have been applied in various fields. With the increasing resistance to antibiotics, the research and application of nano-silver in the field of disinfection and sterilization has attracted more and more attention, and it has become a promising generation of antibacterial drugs. [0003] Studies have shown that nano-silver has a bactericidal effect because of the silver ions contained in nano-silver particles. Silver ions inhibit the reproduction of bacteria through the following three ways: [0004] 1. Silver ions attack the -SH group in the metabolic enzymes inside the ba...
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