7-methoxycoumarin-3-carboxylic acid compound and preparation method thereof

Abstract

The invention relates to a 7-methoxycoumarin-3-carboxylic acid compound and a preparation method thereof. The preparation method comprises the following steps of adding weighed 4-methoxysalicylaldehyde and cyclodiethyl (diethylidene) malonate into a round-bottom flask, adding acetonitrile, stirring at 0 DEG C, adding piperidine after the mixture is dissolved to prepare a large amount of sediment, reacting for one hour, refluxing, standing for one night, finishing a thin-layer chromatography reaction, filtering, drying, and recrystallizing with methanol to obtain 7-methoxycoumarin-3-carboxylic acid. According to the preparation method of the 7-methoxycoumarin-3-carboxylic acid compound, disclosed by the invention, 7-methoxycoumarin-3-carboxylic acid is prepared from the raw materials of 4-methoxysalicylaldehyde, cyclodiethyl (diethylidene) malonate, piperidine and alcohol; a detailed synthesis and purification method is provided; the yield reaches 93%; the preparation method is scientific and reasonable; and detailed theory and practice guidance is provided for following expanded production.

Description

Technical field [0001] The invention belongs to the field of compound preparation, in particular to a compound 7-methoxycoumarin-3-carboxylic acid and a preparation method thereof. Background technique [0002] Gout has the characteristics of latent onset and difficult to cure. Chemicals have the disadvantages of large toxic and side effects to varying degrees. Although traditional Chinese medicine has achieved good results in the treatment of gout, it is difficult to determine the effective ingredients due to the complexity of traditional Chinese medicine and compound prescriptions. Therefore, It is difficult to accurately evaluate the clinical efficacy. At the same time, because the content of Chinese medicine ingredients varies from place of production and batch, the quality of Chinese patent medicines is difficult to control. [0003] According to the search, two patent documents related to this application were found. Among them, document CN1398861 provides a new use of Qinpi ...

AI Technical Summary

Problems solved by technology

[0002] Gout has the characteristics of latent onset and difficult to cure. Chemical drugs have the disadvantages of high toxicity and side effects to varying degrees. Although traditional Chinese medicine has achieved good results in the treatment of gout, it is difficult to determine the active ingredients due to the complexity of traditional Chinese medicine and compound prescriptions. Therefore, It is difficult to accurately evaluate the clinical efficacy. At the same time, because the content of traditional Chinese medicine ingredients varies with the place of origin and batches, it is difficult to control the quality of Chinese patent medicines

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