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Minipig chronic pulmonary hypertension animal model and construction method thereof

A technology of pulmonary hypertension and animal models, which is applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of continuous and long-term observation of the formation process and change characteristics of PH, and achieve strong reproducibility, precise and stable construction, invulnerability effect

Inactive Publication Date: 2013-03-13
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the shortcoming of the acute animal model is that it cannot continuously and long-term observe the formation process and change characteristics of PH

Method used

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  • Minipig chronic pulmonary hypertension animal model and construction method thereof
  • Minipig chronic pulmonary hypertension animal model and construction method thereof
  • Minipig chronic pulmonary hypertension animal model and construction method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Select healthy 2-month-old, male, miniature pigs with a body weight of 4kg, and monocrotaline is dissolved in 55% ethanol to be made into 25mg / ml monocrotaline solution, and described monocrotaline solution is 9.0mg / kg The dose was injected intraperitoneally, and the animal model of chronic pulmonary hypertension in miniature pigs was obtained after the 4th week of monocrotaline injection.

Embodiment 2

[0116] Select healthy 2.5 months old, male, the miniature pig of body weight 5kg, monocrotaline is dissolved in 60% ethanol and is made into the monocrotaline solution of 25mg / ml, described monocrotaline solution is pressed 9.0mg / kg The dose was injected intraperitoneally, and the animal model of chronic pulmonary hypertension in miniature pigs was obtained after the 4th week of monocrotaline injection.

Embodiment 3

[0118] Select healthy 3-month-old, male, mini-pigs with a body weight of 7kg, and monocrotaline is dissolved in 75% ethanol to be made into 25mg / ml monocrotaline solution, and described monocrotaline solution is pressed by 12.5mg / kg The dose was injected intraperitoneally, and the minipig animal model of chronic pulmonary hypertension was obtained after the 5th week of monocrotaline injection.

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Abstract

The invention discloses a minipig chronic pulmonary hypertension animal model. A monocrotaline solution is injected to an abdominal cavity of a male or female healthy minipig which is 1-5 months old and is 3-15kg in weight; and the minipig chronic pulmonary hypertension animal model is obtained after the monocrotaline solution is injected for 4-9 weeks. Correspondingly, the invention discloses a construction method of the minipig chronic pulmonary hypertension animal model. With the adoption of the minipig chronic pulmonary hypertension animal model and the construction method thereof, the body size and structure of the minipig adopted by the minipig chronic pulmonary hypertension animal model are similar to the body size and structure of a human body, so that the minipig chronic pulmonary hypertension animal model can be determined and observed in clinic by clinical equipment; and pathological changes of the minipig chronic pulmonary hypertension animal model approach to clinical pathological changes of human beings, thus being beneficial for observation, treatment and research for a long time.

Description

technical field [0001] The invention relates to the field of animal models of chronic pulmonary hypertension, in particular to a miniature pig animal model of chronic pulmonary hypertension and a construction method thereof. Background technique [0002] Pulmonary hypertension (Pulmonary Hypertension, PH) is one of the major cardiopulmonary vascular diseases in humans. The establishment of PH animal model is a platform for basic and clinical research on the disease. Currently, animal models of PH are divided into two types: acute and chronic. The establishment of acute animal models is mainly based on hypoxic or / and hypobaric hypoxic PH animal models, and rats are more commonly used (Chen Liyan et al. Resveratrol glycosides on phospholipase A_2 in chronic normobaric hypoxic pulmonary hypertension model , nitric oxide and endothelin levels. Chinese Journal of Pathophysiology 2006), followed by experimental animals such as mice and rabbits. [0003] The establishment of chr...

Claims

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Application Information

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IPC IPC(8): A01K67/027A61K31/407A61P11/00A61P9/12
Inventor 李洪涛刘蓉顾为望
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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