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A Attenuated Vaccine Strain of Chicken Infectious Bronchitis Virus

A technology for bronchitis and chicken infectivity, applied in the direction of antiviral agents, viruses/phages, biochemical equipment and methods, etc., can solve the problems that have not been commercialized, and the glandular stomach type IB cannot be effectively controlled, and achieve good products The prospect of chemical development, effective immune protection, and the effect of genetic stability

Active Publication Date: 2015-11-11
YEBIO BIOENG OF QINGDAO
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, there are many researches on vaccines used to prevent glandular gastric type infectious bronchitis at home and abroad, but none of them have been commercialized yet.
At the same time, due to the large number of IBV serotypes, there has been no attenuated strain with good cross-protection on the market, and the gastric type IB cannot be effectively controlled

Method used

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  • A Attenuated Vaccine Strain of Chicken Infectious Bronchitis Virus
  • A Attenuated Vaccine Strain of Chicken Infectious Bronchitis Virus

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Embodiment Construction

[0009] The present invention will be further described below in conjunction with specific embodiments. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0010] One, the screening of chicken infectious bronchitis attenuated YB160 strain of the present invention

[0011] Use 10-11 day-old SPF chicken embryos to carry out continuous passage to attenuate the virulence of infectious bronchitis. In each generation, 4 SPF chicken embryos were inoculated through the allantoic cavity, and the attenuation evaluation was carried out for 160 generations. Get 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 inoculated virus strains to infect 1-day-old SPF chickens. Results From the 80th generation...

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Abstract

The invention relates to an infectious bronchitis virus attenuated vaccine strain. The preservation number of the virus strain is China General Microbiological Culture Collection Center (CGMCC) No.6752. The screened attenuated vaccine strain is used for preparing vaccines for preventing and treating infectious bronchitis. The infectious bronchitis virus attenuated vaccine strain can be passed in chicken bodies continuously whether artificial infection or horizontal transmission infection, the phenomenon of virulence enhancement does not occur, the heredity is stable, and the strain conforms to the standard of no virulence enhancement of infectious bronchitis virus attenuated vaccine strains and can be developed commercially.

Description

technical field [0001] The invention belongs to the technical field of vaccine antigen screening, in particular to a chicken infectious bronchitis virus attenuated vaccine strain. Background technique [0002] Infectious bronchitis (IB) is an acute and highly contagious respiratory disease caused by infectious bronchitis virus (IBV). It is characterized by decreased egg quality and reduced egg quality; sick chickens often die due to respiratory, kidney or digestive tract infections. The disease was first reported in the United States by Schalk et al. in 1931, and in 1936 Beach and Hudson determined that the pathogen of the disease was a virus. So far, the disease has been widely prevalent in the world and has brought serious harm to the chicken industry. In my country, Kuang Ronglu (1972) first discovered the disease in Guangdong; by the late 1970s, Zheng Furong et al. in Hangzhou, Wu Zhida et al. in Shanghai, Ai Guoguang et al. in Beijing, Xin Chaoan et al. IBV. Rong Jun...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N7/00A61K39/215A61P31/14C12R1/93
Inventor 范根成杜元钊宋新宇宫晓孙健王红徐保娟
Owner YEBIO BIOENG OF QINGDAO
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