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Use of green coffee beans for regulating skin pigmentation disorders

A skin pigment, coffee bean technology, applied in the food supplement and/or food field, which can solve the problems of irritating side effects of topical active agents, not fully satisfactory, etc.

Inactive Publication Date: 2013-05-01
SOC DES PROD NESTLE SA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the currently available methods of treatment are not entirely satisfactory, especially with regard to the side effects that often accompany them, such as the irritating side effects of some topical active agents

Method used

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  • Use of green coffee beans for regulating skin pigmentation disorders
  • Use of green coffee beans for regulating skin pigmentation disorders
  • Use of green coffee beans for regulating skin pigmentation disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1: Effects on skin pigmentation

[0071] To assess the potential beneficial effects of ingredients on skin depigmentation or promoting hyperpigmentation, we performed 2 experiments with 2D cultures of murine melanocytes (B16): 1 - assessing melanogenesis and 2 - assessing tyrosinase production.

[0072] 1. cell culture conditions

[0073]B16 cells were cultured in DMEM containing 1 g / L glucose without phenol red and supplemented with 10% fetal calf serum in a humidified culture room at 37 °C with 5% CO 2 cultivated under conditions.

[0074] 2. Melanin production by the B16 murine melanocyte line

[0075] Cells were incubated with selected components or assay reference (kojic acid, 400 μg / mL) in the presence or absence of the MSH analog NDP-MSH for 72 hours. The total amount of melanin (extracellular and intracellular) was assessed by measuring the optical density at 405 nm of each sample compared to a melanin standard in the presence or absence of NDP-...

Embodiment 2

[0087] Example 2: Effects on skin barrier function and moisture content

[0088] Using 2D cultures of human primary epidermal keratinocytes to assess the potential beneficial effects of the extract of Example 1 on skin barrier function and skin moisture content, we conducted 3 experiments: 1 - Evaluation of human primary epidermal keratinocytes Synthetic filaggrin, 2-assessment of hyaluronic acid secreted by human prodermal keratinocytes and 3-assessment of CD44 (hyaluronan receptor) produced by human prodermal keratinocytes.

[0089] cell culture conditions

[0090] Human epidermal keratinocytes were cultured in restricted (control) keratinocyte SFM medium in a humidified culture room at 37°C, containing 5% CO 2 cultivated under conditions.

[0091] Synthesis of filaggrin by human epidermal keratinocytes

[0092] Cells were mixed with selected components or assay references (CaCl 2 , 1.5mM) were incubated together for 144 hours. Filaggrin production was assessed by...

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Abstract

The present invention relates generally to the field of food supplements and / or food products for cosmetic purpose. More specifically, the present invention aims to provide an ingredient containing green coffee beans or an extract thereof for preventing and / or treating hyper-pigmentation of skin, skin color imperfections such as age-spots and other skin disorders characterized by abnormal pigments. The present invention also aims at improving skin tone as well as providing a skin lightening or whitening agent.

Description

[0001] The present invention relates generally to the field of food supplements and / or food products for cosmetic purposes. More specifically, the present invention aims to provide a composition comprising green coffee beans or an extract thereof for the prevention and / or treatment of hyperpigmentation of the skin, skin color defects such as age spots and other skin conditions characterized by abnormal pigmentation . It is also an object of the present invention to improve skin tone and to provide skin lightening or lightening agents. Background of the invention [0002] Skin color is primarily determined by the amount and type of melanin, a brown pigment present in the skin. The less the amount of melanin, the whiter the skin, and the more the melanin, the darker the skin. In addition, hyperpigmentation of the skin is also caused by the overexpression or accumulation of melanin in the skin. Therefore, the pathways involved in melanin production have been the target of many...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/97A61K8/99A61Q19/02A61Q19/08
CPCA61K8/97A61K2800/88A61Q19/02A61K8/99A61Q19/08A61K8/9789A61P3/00A61P17/02A61P17/16
Inventor K·克雷亨比尔O·莫罗克斯A·牟迪克里弗F·迪欧尼斯M·吉塔尔
Owner SOC DES PROD NESTLE SA
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