Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses

A technology for arctigenin and trephine aglycone, which is applied in the application, food preparation, antiviral agent and other directions, can solve the problems such as no anti-hepatitis C virus effect, etc., and achieve a remarkable anti-hepatitis C virus activity. Effect

Inactive Publication Date: 2014-08-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there have been no relevant reports on the anti-hepatitis C virus effects of the dibenzylbutyrolactone compounds, tertogenin, tertogenin, and arctigenin in scorpion vine.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Anti-hepatitis C virus test of strogenin, arctigenin and stroganoside

[0029] 1. Experimental drugs, reagents and materials

[0030] 1. Compounds: strogenin, arctigenin, strogenin.

[0031] 2. Cell line Huh7, human liver cancer cell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY, 2011; 85(6): 2793-2802; Jin Zhong, Pablo Gastaminza, Guofeng Cheng, et al. Robust hepatitis C virus infection in vitro, PNAS, 2005; 102(26):9294-9299).

[0032] 3. Cell culture medium, prepared, which contains 10% fetal bovine serum, 0.03% glutamine, non-essential amino acids, ampicillin and streptomycin 100U / ml, adjust the pH to 7.4.

[0033] 4. Cell digestion solution, prepared, containing 0.25% trypsin, prepared with phosphate buffer.

[0034] 5. HCVcc: cell-cultured infectious hepatitis C virus (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the application of the dibenzylbutyrolactone compounds tertigenin, arctigenin or terrigenin in the preparation of medicines for preventing and treating hepatitis virus, especially the application in the preparation of medicines for preventing and treating hepatitis C virus. The three compounds can also be used to prepare liver protection food or health products. The present invention has the advantages of: providing new applications of dibenzylbutyrolactone compounds strogenin, arctigenin and strogenin, and it has been confirmed by anti-hepatitis C virus test research that all three compounds have It can significantly inhibit the activity of hepatitis C virus, and provides a new source of active ingredients for the research and development of anti-hepatitis C virus drugs, liver-protecting food and health products.

Description

technical field [0001] The present invention relates to the new application of dibenzylbutyrolactone compound strogenin, arctigenin and strogenin, specifically, the dibenzylbutyrolactone compound strogenin, arctigenin Application of aglycone and tergoside in the preparation of drugs for preventing and treating hepatitis virus. Background technique [0002] Trachelogenin (trachelogenin), arctigenin (arctigenin), and tracheloside (tracheloside) are derived from trachelogenin, a plant of the family Apocynaceae. Trachelospermum jasminoside Dibenzylbutyrolactones isolated from (Lindl.) Lem, details can be found in the following literature: ①Tan XQ (Tan Xingqi), Chen HS (Chen Haisheng), Liu RH (Liu Runhui), et al. Lignans from Trachelospermum jasminoides [J]. Planta Med. 2005; 71(1):93-95; ②Inagaki I, Hisada Y, Nishibe S. Lignans of Trachelospermum asiaticum var. intermedium . I. Isolation and structures of Arctiin, Matairesinoside and Tracheloside[J]. Chem Pharm Bull 1972; 2...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P31/14A23L1/30
Inventor 陈海生朱勇喆谭兴起钱汐晶金永生戚中田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products