Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses

A technology for arctigenin and trephine aglycone, which is applied in the application, food preparation, antiviral agent and other directions, can solve the problems such as no anti-hepatitis C virus effect, etc., and achieve a remarkable anti-hepatitis C virus activity. Effect

Inactive Publication Date: 2014-08-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there have been no relevant reports on the anti-hepatitis C virus effects of the dibenzylbutyrolactone compounds, tertogenin, tertogenin, and arctigenin in scorpion vine.

Method used

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  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Anti-hepatitis C virus test of strogenin, arctigenin and stroganoside

[0029] 1. Experimental drugs, reagents and materials

[0030] 1. Compounds: strogenin, arctigenin, strogenin.

[0031] 2. Cell line Huh7, human liver cancer cell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY, 2011; 85(6): 2793-2802; Jin Zhong, Pablo Gastaminza, Guofeng Cheng, et al. Robust hepatitis C virus infection in vitro, PNAS, 2005; 102(26):9294-9299).

[0032] 3. Cell culture medium, prepared, which contains 10% fetal bovine serum, 0.03% glutamine, non-essential amino acids, ampicillin and streptomycin 100U / ml, adjust the pH to 7.4.

[0033] 4. Cell digestion solution, prepared, containing 0.25% trypsin, prepared with phosphate buffer.

[0034] 5. HCVcc: cell-cultured infectious hepatitis C virus (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tu...

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Abstract

The present invention relates to the application of the dibenzylbutyrolactone compounds tertigenin, arctigenin or terrigenin in the preparation of medicines for preventing and treating hepatitis virus, especially the application in the preparation of medicines for preventing and treating hepatitis C virus. The three compounds can also be used to prepare liver protection food or health products. The present invention has the advantages of: providing new applications of dibenzylbutyrolactone compounds strogenin, arctigenin and strogenin, and it has been confirmed by anti-hepatitis C virus test research that all three compounds have It can significantly inhibit the activity of hepatitis C virus, and provides a new source of active ingredients for the research and development of anti-hepatitis C virus drugs, liver-protecting food and health products.

Description

technical field [0001] The present invention relates to the new application of dibenzylbutyrolactone compound strogenin, arctigenin and strogenin, specifically, the dibenzylbutyrolactone compound strogenin, arctigenin Application of aglycone and tergoside in the preparation of drugs for preventing and treating hepatitis virus. Background technique [0002] Trachelogenin (trachelogenin), arctigenin (arctigenin), and tracheloside (tracheloside) are derived from trachelogenin, a plant of the family Apocynaceae. Trachelospermum jasminoside Dibenzylbutyrolactones isolated from (Lindl.) Lem, details can be found in the following literature: ①Tan XQ (Tan Xingqi), Chen HS (Chen Haisheng), Liu RH (Liu Runhui), et al. Lignans from Trachelospermum jasminoides [J]. Planta Med. 2005; 71(1):93-95; ②Inagaki I, Hisada Y, Nishibe S. Lignans of Trachelospermum asiaticum var. intermedium . I. Isolation and structures of Arctiin, Matairesinoside and Tracheloside[J]. Chem Pharm Bull 1972; 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P31/14A23L1/30
Inventor 陈海生朱勇喆谭兴起钱汐晶金永生戚中田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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