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Application of ganoderma acid a in the preparation of drugs for preventing and treating hepatitis C virus

The technology of hepatitis C virus and ganoderma lucidum acid is applied in the fields of natural medicinal chemistry and medicine, and can solve the problems of no anti-hepatitis C virus effect and the like, and achieve the effect of good medicinal prospect and strong pharmacological effect.

Active Publication Date: 2019-05-14
JINHUA SHOUXIANGU PHAMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no relevant report that the tetracyclic triterpene compound ganoderic acid A in Ganoderma lucidum has anti-hepatitis C virus effects

Method used

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  • Application of ganoderma acid a in the preparation of drugs for preventing and treating hepatitis C virus
  • Application of ganoderma acid a in the preparation of drugs for preventing and treating hepatitis C virus
  • Application of ganoderma acid a in the preparation of drugs for preventing and treating hepatitis C virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Ganoderma acid A anti-hepatitis C virus test

[0021] 1 Experimental drugs, reagents and materials

[0022] 1.1 Compound: Ganoderma acid A.

[0023] 1.2 Cell line Huh7, human liver cancer cell line (see: Y.M.Tong, Y.Z.Zhu, X.S.Xiaetal.TupaiaCD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C VirusInfection, J.Virol, 2011, 85(6): 2793-2802; Z.Jin, P.Gastaminza, G.F.Chenget al, Robus the patitis Cvirusin infection in vitro, PNAS, 2005, 102(26):9294-9299.); cell line 293T, human embryonic kidney cell line (detailed See Y.M.Tong, Y.Z.Zhu, X.S.Xia et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, J.Virol, 2011, 85(6):2793-2802; F.L.Graham, J.Smiley , V. Russell et al, J. Gen. Virol 1977; 36:59-74).

[0024] 1.3 Cell culture medium, prepared, which contains 10% fetal bovine serum, 0.03% glutamine, non-essential amino acids, ampicillin and streptomycin 100U / ml, adjust the pH to 7.4.

[0025] 1.4. Cell digestion soluti...

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PUM

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Abstract

The invention discloses a new medical use of ganoderic acid A represented by formula (I), and provides an application of ganoderic acid A in the preparation of hepatitis C virus treatment or prevention drugs, and an application of ganoderic acid A in the preparation of hepatitis C virus prevention foods or health products.

Description

(1) Technical field [0001] The invention relates to the technical fields of natural medicinal chemistry and medicine, in particular to the application of ganoderic acid A (ganoderic acid A) in the preparation of medicines for treating or preventing hepatitis C virus diseases. (2) Background technology [0002] Ganoderic acid A (ganoderic acidA) is a tetracyclic triterpenoid compound obtained from the cultivation of Polyporaceae Ganoderma fungus Ganoderma lucidum (Leyssex Fr.) Karst. The structure of this compound has been reported (see: Li Dandan, Chizhi fruiting body Research on the chemical constituents of Chizhi, China Chemical Trade, 2013; 5:159-160; Chen Man et al., Research on the chemical constituents of the fruiting bodies of Chizhi, Shizhen Guoyi Guoyao, 2009; 20(7):1771-1773). [0003] It has been reported that the crude extract of Ganoderma lucidum triterpene acid has a certain protective effect on acute liver injury, and its mechanism may be related to its anti-l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61P31/14A23L33/10
Inventor 李振皓李明焱王瑛陈海生朱勇喆戚中田
Owner JINHUA SHOUXIANGU PHAMACEUTICAL CO LTD
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