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Antiepileptic medicine and preparation method thereof

A technology of antiepileptic drugs and antioxidants, applied in the field of medicine, can solve problems such as chronic adverse reactions, unsuitable for long-term use, and short duration of curative effect, so as to achieve no serious or chronic adverse reactions, facilitate rapid diffusion, and have remarkable effects Effect

Inactive Publication Date: 2013-06-05
张晓光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of neuroscience and clinical pharmacology, the drugs used for the treatment of epilepsy are gradually showing a trend of diversification, but at present they are still dominated by single drugs, and single antiepileptic drugs are highly selective. Due to the pathogenesis of epilepsy Complicated, ineffective targeted therapy
The current common compound antiepileptic drugs have a short duration of efficacy, are not stable enough to control the disease, and have a variety of chronic adverse reactions, so they are not suitable for long-term use

Method used

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  • Antiepileptic medicine and preparation method thereof

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preparation example Construction

[0019] A kind of preparation method of antiepileptic drug of the present invention, concrete steps are as follows:

[0020] (1) Take Zengqing and domestic termites by weight, crush them to 80-100 mesh, mix them evenly and add them to the extraction kettle, then add water by weight to the extraction kettle, close the extraction kettle, and heat to 110-130°C , the pressure is 0.3-0.6MPa, keep for 8-10min, cool down to room temperature naturally, and obtain the extract after centrifugation;

[0021] (2) Heat the extract to 50°C again, add antioxidants, sweeteners, and levetiracetam in parts by weight while stirring, continue stirring for 30-50 minutes until completely dissolved, wet sterilize, and cool to room temperature , to obtain the oral solution of antiepileptic drugs.

[0022] The preparation method of an antiepileptic drug of the present invention has a simple and easy-to-operate preparation process, can fully extract active ingredients in traditional Chinese medicines, ...

Embodiment 1

[0030] Embodiment 1 Concrete steps are as follows:

[0031] (1) Take 15g Zengqing and 18g domestic termites, grind them to 80 mesh, mix them evenly, add them to the extraction kettle, then add 100g water to the extraction kettle, close the extraction kettle, heat to 110°C, and keep the pressure at 0.3MPa. 8min, naturally cooled to room temperature, and after centrifugation, 120.9g of extract was obtained;

[0032] (2) Heat 120.9g of the extract to 50°C again, add 5g of dibutyl hydroxytoluene, 6g of xylitol, and 10g of levetiracetam in turn under stirring, continue stirring for 30 minutes until completely dissolved, wet sterilize, and cool To room temperature, the oral liquid of 138.4g antiepileptic drugs was obtained.

Embodiment 2

[0033] Embodiment 2 Concrete steps are as follows:

[0034] (1) Take 20g Zengqing and 24g domestic termites, grind them to 100 mesh, mix them evenly and add them to the extraction kettle, then add 120g water to the extraction kettle, close the extraction kettle, heat to 130°C, and the pressure is 0.6MPa, keep 10min, naturally cooled to room temperature, and after centrifugation, 153 g of extract was obtained;

[0035] (2) Heat 143g of the extract to 50°C again, add 9g of tert-butylhydroquinone, 11g of stevioside, and 18g of levetiracetam in turn while stirring, continue stirring for 50min until completely dissolved, wet sterilize, and cool To room temperature, the oral liquid of 189g antiepileptic drugs was obtained.

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Abstract

The invention provides an antiepileptic medicine and a preparation method thereof. The antiepileptic medicine adopts azurite ore, Formosan white ant, and levetiracetam as effective components. The medicine comprises the components of, by weight, 15-20 parts of azurite ore, 18-24 parts of Formosan white ant, 10-18 parts of levetiracetam, 5-9 parts of an antioxidant, 6-11 parts of a sweetening agent, and 100-120 parts of water. The preparation method comprises the steps that: azurite ore and Formosan white ant are crushed and well mixed; the mixture is added into an extraction kettle; water is added into the extraction kettle, and the kettle is sealed; the kettle is heated, a pressure is 0.3-0.6MPa, and the state is maintained for 8-10min; the temperature is reduced to room temperature, and centrifugation is carried out, such that an extraction liquid is obtained; the extraction liquid is heated to 50 DEG C; the antioxidant, the sweetening agent, and levetiracetam are added, and the mixture is stirred until completely dissolved; wet sterilization is carried out, and the product is cooled, such that the antiepileptic oral liquid is obtained. The antiepileptic medicine provided by the invention has broad-spectrum resistance, and substantial antiepileptic effect. The medicine can be taken for a long time, and causes no severe or chronic adverse reaction.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an antiepileptic drug and a preparation method thereof. Background technique [0002] As a common nervous system disease, epilepsy is commonly treated with western medicine, surgery and traditional Chinese medicine. However, due to the characteristics of rapid and recurrent epileptic seizures, surgical treatment has obvious disadvantages, so drug treatment is the main treatment. . With the development of neuroscience and clinical pharmacology, the drugs used for the treatment of epilepsy are gradually showing a trend of diversification, but at present they are still dominated by single drugs, and single antiepileptic drugs are highly selective. Due to the pathogenesis of epilepsy Complex, can not be effective targeted treatment. The current common compound antiepileptic drugs have a short duration of efficacy, are not stable enough to control the disease, and have a variety ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P25/08A61K33/34A61K31/4015
Inventor 张晓光
Owner 张晓光
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