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Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease

A technology of gastroesophageal reflux and composition, which is applied in the direction of drug combination, food ingredients containing natural extracts, food science, etc., and can solve problems such as increasing the risk of fractures

Inactive Publication Date: 2013-09-25
GREEN CROSS HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the US FDA (Food and Drug Administration) report, long-term (such as one year or more) use of drugs based on proton pump inhibitors or large doses will increase the risk of fractures

Method used

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  • Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease
  • Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease
  • Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] The preparation of honeysuckle 70% ethanol aqueous solution extract

[0089]The honeysuckle used in the present invention is the dried flower buds before flowering. The powder obtained by crushing is finely cut according to a certain size, 1 kg is put into an extraction container, 10 L of 70% ethanol aqueous solution is added, and stirred for 6 hours at 60° C., while stirring, side extraction. The resulting product was filtered with filter paper to obtain an extract. Repeat the extraction process 3 times. Thereafter, the solvent was concentrated and dried under reduced pressure to obtain 300 g of a 70% ethanol aqueous extract.

Embodiment 2-3

[0090] preparation of honeysuckle alcohol extract

[0091] In the same manner as in Example 1, but using ethanol and methanol instead of the 70% aqueous ethanol solution in Example 1 as the extraction solvent, respectively, 320 g of ethanol extract and 340 g of methanol extract were obtained.

Embodiment 4

[0092] Preparation of Honeysuckle Extract Ethyl Acetate Fraction

[0093] After adding 3 L of water to the 70% ethanol aqueous extract of Example 1 for suspension, add 3 L of ethyl acetate, repeat the extraction 3 times, perform vacuum filtration with filter paper, and remove the solvent of the obtained ethyl acetate extract , 30 g of an ethyl acetate fraction was obtained as a residue (debris).

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Abstract

Disclosed is a composition for treating or preventing gastroesophageal reflux disease, which includes an organic solvent extract of Lonicerae Flos Thunberg. A fraction of the disclosed extract can be very effectively used for treating, preventing, or improving gastroesophageal reflux disease without side effects.

Description

technical field [0001] The present invention relates to a composition for treating or preventing gastroesophageal reflux disease, which contains a fraction of Lonicera japonica Thunberg or obtained from The compound isolated in this fraction is used as an active ingredient. Specifically, the present invention relates to a composition for treating or preventing gastroesophageal reflux disease, which contains the honeysuckle fraction or at least one selected from the following: Group of compounds as active ingredients: 3,5-di-O-caffeoylquinic acid and 4,5-di-O-caffeoylquinic acid. Background technique [0002] Generally, gastroesophageal reflux disease is a disease in which stomach contents (acid and pepsin) reflux into the esophagus, causing various clinical symptoms (such as heartburn, epigastric pain) and mucosal changes. The longer the mucous membranes are exposed to acid, the more severe the lesions, potentially leading to chronic disease. Usually the main cause of GER...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K31/19A61K31/185A61P1/08
CPCA23V2002/00A61K31/216A61K31/222A61K31/232A61K36/355A23L33/105A61P1/04A61P1/08A61P43/00A23V2200/3204A23V2250/21A61K45/06
Inventor 刘泳孝金点溶金先玉金珠英朴宣奎张珉廷
Owner GREEN CROSS HEALTH SCI
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