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Composition for impotence and premature ejaculation

A technology for impotence and premature ejaculation, applied in drug combinations, medical preparations containing active ingredients, organic active ingredients, etc.

Active Publication Date: 2015-04-01
北京元延医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although impotence and premature ejaculation are often accompanied by sexual dysfunction, there is currently no effective treatment for both disorders

Method used

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  • Composition for impotence and premature ejaculation
  • Composition for impotence and premature ejaculation
  • Composition for impotence and premature ejaculation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: preparation composition of the present invention

[0055] prescription:

[0056]

[0057]

[0058] Preparation method:

[0059] Step 1: Crush each material separately and pass through a 100-mesh sieve for later use.

[0060] Step 2: fully mix the active ingredient and the filler evenly, use the binder solution to make a soft material, granulate, and dry to obtain dry granules.

[0061] Step 3: Mix the dry granules obtained in step 2 with disintegrant and lubricant evenly, press 2 / 3 of the material into tablets, and put 1 / 3 of the material into capsules. In the dissolution test, it has been found that there is no significant difference in the dissolution of tablets and capsules (the difference in dissolution is less than 2 percentage points, so tablets can be used in the present invention to investigate the dissolution performance of the composition of the present invention).

[0062] Each tablet or capsule contains 45mg of dapoxetine hydrochlori...

Embodiment 2

[0063] Embodiment 2: preparation composition of the present invention

[0064] prescription:

[0065] Dapoxetine Hydrochloride

[0066] Preparation method: basically carry out with reference to the method of Example 1, and make tablets. In addition to compressing each tablet containing the amount in the above prescription table, 1 / 3 of the mixed granules are compressed into tablets each containing 90 mg of avanafil.

Embodiment 3

[0067] Embodiment 3: preparation composition of the present invention

[0068] prescription:

[0069] Dapoxetine Hydrochloride

[0070] Preparation method: basically carry out with reference to the method of Example 1, and make tablets. In addition to compressing each tablet containing the amount in the above prescription table, 1 / 3 of the mixed granules are compressed into tablets each containing 90 mg of avanafil.

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PUM

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Abstract

The invention relates to a composition for impotence and premature ejaculation. Specifically, the invention relates to a use of combination of dapoxetine or medical salts thereof and avanafil in preparation of a medicament for preventing or treating impotence and premature ejaculation, and further relates to a composition including the dapoxetine or medical salts thereof and avanafil. The composition disclosed by the invention has the characteristic of being excellent.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating impotence and premature ejaculation, in particular, the composition contains avanafil, dapoxetine or a pharmaceutically acceptable salt thereof. Background technique [0002] According to the survey, among the male population aged 18 to 59, 35% of the males suffer from sexual dysfunction. Males suffer from impotence (erectile dysfunction, ED, which usually manifests as inability to erect the penis so that effective sexual intercourse cannot be performed) and premature ejaculation (PE). , usually manifested as too fast ejaculation, especially ejaculation within less than 5 minutes, especially less than 2 minutes, especially less than 1 minute) is the most common, high incidence, multiple recurrences, and often accompanied by occurrence, for The quality of sexual life of couples has a greater impact and is an important factor in male infertility. In recent years, patients with impotence ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/506A61P15/10A61K31/138
Inventor 王立强
Owner 北京元延医药科技股份有限公司
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