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Composition and medicine for strengthening heart and preventing and curing chronic heart failure and preparation method

A technology for chronic heart failure and composition, applied in the field of composition of natural pharmaceutical ingredients, can solve problems such as toxicity safety, loss of beneficial ingredients, influence on drug efficacy and safety, etc.

Active Publication Date: 2013-11-27
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant's in-depth research found that due to the characteristics of the medicinal raw material aconite (prepared aconite and / or raw aconite), especially the prepared aconite, after decocting in ordinary water in a conventional manner, the decoction is acidic or even strong Therefore, the diester-type alkaloids in the water decoction are relatively stable. Even if they are decocted for a long time, not only the detoxification effect is not ideal, but also the beneficial ingredients will be easily lost.
Because diester alkaloids have obvious cardiotoxicity, these ginseng / aconite compositions containing diester alkaloids have certain toxicity and potential safety hazards, which also affect the efficacy and safety of drugs

Method used

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  • Composition and medicine for strengthening heart and preventing and curing chronic heart failure and preparation method
  • Composition and medicine for strengthening heart and preventing and curing chronic heart failure and preparation method
  • Composition and medicine for strengthening heart and preventing and curing chronic heart failure and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Take 1 kg of red ginseng, add 12 times of water to decoct twice, each time for 2 hours, filter, combine the filtrate, put it on a HPD100 macroporous adsorption resin column, first wash and remove impurities with 3 times the volume of the column bed, and then use 70% For ethanol elution, collect 3 times of column bed volume of ethanol eluate, recover ethanol, concentrate and dry to obtain ginsenoside extract. Take another 2 kg of succulents, add 8 times the amount of water, adjust the pH value to 6.5-7.5 with sodium hydroxide solution at the beginning of decoction and during the decoction process, decoct 3 times, each time for 1 hour, filter, and combine the filtrate, Recover water, concentrate to a relative density of about 1.20, add 95% (v, the same below) ethanol to make the alcohol content reach 80-85%, stir well, let stand overnight, filter, recover ethanol, concentrate, dry, Aconite extract free from diester alkaloids is obtained.

[0028] The composition of the p...

Embodiment 2

[0030]Take 1 kg of red ginseng, add 12 times of water to decoct twice, each time for 2 hours, filter, combine the filtrate, put it on a HPD100 macroporous adsorption resin column, first wash and remove impurities with 3 times the volume of the column bed, and then use 70% For ethanol elution, collect 3 times of column bed volume of ethanol eluate, recover ethanol, concentrate and dry to obtain ginsenoside extract. Take another 2 kg of succulents, add 8 times the amount of water, adjust the pH value to 6.5-7.5 with sodium hydroxide solution at the beginning of decoction and during the decoction process, decoct 3 times, each time for 1 hour, filter, and combine the filtrate, On the HPD100 macroporous adsorption resin column, first wash and remove impurities with 3 times the volume of the column bed, then elute with 70% ethanol, collect the ethanol eluate with 3 times the volume of the column bed, recover the ethanol, concentrate, and dry to obtain Aconite extract containing dies...

Embodiment 3

[0033] Take 1 kg of red ginseng, add 8 times the amount of water to decoct 3 times, each time for 1 hour, filter, combine the filtrate, put it on a D101 macroporous adsorption resin column, wash and remove impurities with 2 times the volume of the column bed, and then use 60 % ethanol elution, collect the ethanol eluate of 3 times column bed volume, reclaim ethanol, concentrate, dry, obtain ginsenoside extract. Take another 3kg of Heifu Tablets, add 12 times the amount of water, adjust the pH value to 8-9 with sodium carbonate solution at the beginning of decoction and during the decoction process, decoct for 3 hours, filter, add pH 2-3 water to the dregs of the medicine 6 Double the amount of decoction twice, each time for 1 hour, filter, combine the filtrate, combine the filtrate, recover the water, concentrate to a relative density of about 1.15, add 90-95% ethanol to make the alcohol content reach about 70%, fully stir, Stand overnight, filter, recover ethanol, concentrate...

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Abstract

The invention relates to a composition and medicine for strengthening heart and preventing and curing chronic heart failure and a preparation method. The composition comprises ginsenoside extract and radix aconite lateralis preparata extract containing no diester-type alkaloid, wherein the ratio in part by weight of the raw material of ginsenoside extract to that of radix aconite lateralis preparata extract is 1:(1-5). The composition can be used as an effective component to prepare the medicine with corresponding functions together with acceptable auxiliary components. During preparation, ginsenoside extract can be obtained in such a way that ethanol / water extract of ginseng or red ginseng is separated by macroporous resin; radix aconite lateralis preparata extract containing no diester-type alkaloid is obtained in such a way that decoction of medicinal raw material radix aconite lateralis preparata is deposited by ethanol or separated by macroporous resin under the condition of maintaining the pH value of 6.5-9. Experiments show that the composition / medicine has a remarkable synergistic effect in the aspects of heart strengthening, chronic heart failure curing, cardio-pulmonary-cerebral resuscitation and the like, the efficacy is superior to that of radix aconite lateralis preparata total alkaloid extract obtained in a conventional manner, and the toxicity is remarkably reduced.

Description

technical field [0001] The invention relates to a composition of natural medicinal ingredients, in particular to a composition capable of strengthening the heart and preventing and treating chronic heart failure, as well as a corresponding medicine and a preparation method. Background technique [0002] Ginseng and aconite are commonly used traditional Chinese medicines. Ginseng has the functions of invigorating vital energy, recovering pulse and strengthening the spleen, nourishing the spleen and lung, promoting body fluid and nourishing blood, calming the nerves and improving intelligence. The main active ingredient is ginsenoside. Aconitum has the functions of recovering yang and resuscitating adverse events, tonifying fire and tonifying yang, dispelling cold and relieving pain. Aconitum is a toxic traditional Chinese medicine, and its main toxic components are diester-type alkaloids (aconitine, neoaconitine, hypoaconitine). The active ingredients of aconite for recoveri...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P9/04
Inventor 易进海黄志芳陈燕刘玉红刘云华
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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