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Use of the cell fraction of Lactobacillus gasseri in the manufacture of a composition for alleviating delayed-type hypersensitivity

A Lactobacillus gasseri, allergy technology, applied in the directions of Lactobacillus, dairy products, drug combinations, etc.

Active Publication Date: 2016-09-28
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, there is no report on the reduction of delayed hypersensitivity reaction or the suppression of delayed hypersensitivity reaction by microorganisms such as lactic acid bacteria

Method used

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  • Use of the cell fraction of Lactobacillus gasseri in the manufacture of a composition for alleviating delayed-type hypersensitivity
  • Use of the cell fraction of Lactobacillus gasseri in the manufacture of a composition for alleviating delayed-type hypersensitivity
  • Use of the cell fraction of Lactobacillus gasseri in the manufacture of a composition for alleviating delayed-type hypersensitivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0093] Suppression of splenic CD4 + The effect of the proliferative response of T cells

[0094] 1. Materials and methods

[0095] 〔animal〕

[0096] Female BALB / c mice aged 8-10 weeks were purchased from CLEA, Japan. 8-10 weeks-old female DO11.10TCR transgenic mice express I-A specific for 323-339 positions of ovalbumin (OVA) d Mice restricted to the T cell receptor (TCR) αβ chain (derived from BALB / c mice).

[0097] 〔Preparation of heat-treated bacterial suspension and its fractions〕

[0098] The heat-treated bacteria (3 mg in terms of dry weight) were collected by centrifugation and suspended in physiological saline at a concentration of 5 mg / ml. 0.5 g of glass beads (0.1 mm in diameter, Sigma-Aldrich, St. Louis, MO) were added to the cell suspension, and crushed with a Multi-beads shocker (Yasui Machinery) to obtain a crushed cell liquid. The pulverized liquid was centrifuged at 300×g for 10 minutes at 4°C, and fractionated into a supernatant and a precipitate fr...

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Abstract

The present invention clarifies that the bacterial cell fraction of Lactobacillus gasseri, which has food experience and has been ingested for a long time and has clear safety, suppresses delayed hypersensitivity reactions. Therefore, this invention provides the alleviating agent of delayed type hypersensitivity which contains the cell fraction of Lactobacillus gasseri. In addition, the present invention provides a food composition for alleviating delayed-type hypersensitivity reaction comprising a cell fraction of Lactobacillus gasseri. In addition, it was also found out in the present invention that among the bacterial cell fractions, the RNA fraction exhibits a particularly high effect of suppressing delayed hypersensitivity reactions.

Description

technical field [0001] The present invention relates to a drug for alleviating delayed hypersensitivity, a food composition for alleviating delayed hypersensitivity containing the same, and the like. Background technique [0002] Anaphylaxis, that is, allergic diseases, is classified into types I to IV, and their respective pathogenesis and symptoms are different. In type I allergy, antigen-specific IgE is induced due to antigen sensitization, and the produced IgE binds to the surface of mast cells. There, when the antigen invaded into the body is captured by the specific IgE, chemical mediators such as histamine are secreted by mast cells. As a result, increased vascular permeability, bronchoconstriction, and immediate allergic reactions such as sneezing and nasal discharge are caused. [0003] On the other hand, type IV allergy is a disease caused by a delayed hypersensitivity reaction, and is a disease in which antigen-specific T cells activate macrophages and the like ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747
CPCA23C9/1234A61K35/747A23L33/135A61P37/08A61P43/00A23V2400/145
Inventor 指原纪宏池上秀二户塚护吉田绫子清水诚
Owner MEIJI CO LTD
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