Pharmaceutical composition for preventing and treating Parkinson's disease and preparation method thereof

A technology for Parkinson's disease and a composition, applied in the field of medical preparations, can solve the problems of unfavorable quality control and production, large prescription, high cost and safety hazard, and achieve the effects of being beneficial to quality control, less medicinal taste and remarkable effect

Active Publication Date: 2014-04-16
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the medicine described in this patent application contains two traditional Chinese medicines of tortoise shell and calamus calamus, the medicine not only has a large prescription, but also contains many expensive and toxic traditional Chinese medicines, which has high cost and safety hazards and is not conducive to effective quality. control and production

Method used

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  • Pharmaceutical composition for preventing and treating Parkinson's disease and preparation method thereof
  • Pharmaceutical composition for preventing and treating Parkinson's disease and preparation method thereof
  • Pharmaceutical composition for preventing and treating Parkinson's disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] (1) Prescription: Shichangpu 250g, turtle shell 750g.

[0081] (2) Preparation method:

[0082] (1) Extract the volatile oil of Acorus calamus with carbon dioxide supercritical extraction method or steam distillation; weigh β-cyclodextrin according to 10% of the weight of Acorus calamus, put it in a container, add purified water, and heat it in a boiling water bath to make it Dissolve, place at 25°C, stir at constant temperature for 15 minutes, slowly inject the volatile oil of Acorus calamus into β-cyclodextrin, continue to stir at constant temperature for 30 minutes, take it out, cool to 25°C, quickly filter, rinse with a small amount of water first, Then wash with ether and dry to obtain the clathrate of calamus heavy volatile oil;

[0083] (2) Take tortoise shell and crush, sieve, add appropriate amount of water to soak, add 2 times the water to decoct twice, the first time for 2 hours, the second time for 1.5 hours, filter, combine the filtrate, concentrate to a r...

Embodiment 2

[0086] (1) Prescription: Shichangpu 300g, turtle shell 700g.

[0087] (2) Preparation method:

[0088] (1) Extract the volatile oil of Acorus calamus with carbon dioxide supercritical extraction method or steam distillation; weigh β-cyclodextrin according to 12% of the weight of Acorus calamus, put it in a container, add purified water, and heat it in a boiling water bath to make it Dissolve, place at 37°C, stir at constant temperature for 20 minutes, slowly inject the volatile oil of Acorus calamus into β-cyclodextrin, continue to stir at constant temperature for 35 minutes, take it out, cool to 25°C, quickly filter, rinse with a small amount of water first, Then wash with ether and dry to obtain the clathrate of calamus heavy volatile oil;

[0089] (2) Take tortoise shell and crush, sieve, add appropriate amount of water to soak, add 2.5 times of water to decoct twice, the first time for 2 hours, the second time for 1.5 hours, filter, combine the filtrate, concentrate to a ...

Embodiment 3

[0092] (1) Prescription: Shichangpu 350g, turtle shell 650g.

[0093] (2) Preparation method:

[0094] (1) Extract the volatile oil of Acorus calamus with carbon dioxide supercritical extraction method or steam distillation; weigh β-cyclodextrin according to 13% of the weight of Acorus calamus, put it in a container, add purified water, and heat it in a boiling water bath to make it Dissolve, place at 40°C, stir at constant temperature for 25 minutes, slowly inject the volatile oil of Acorus calamus into β-cyclodextrin, continue to stir at constant temperature for 40 minutes, take it out, cool to 25°C, quickly filter, rinse with a small amount of water first, Then wash with ether and dry to obtain the clathrate of calamus heavy volatile oil;

[0095] (2) Take tortoise shell and crush, sieve, add appropriate amount of water to soak, add 3 times the water to decoct twice, the first time for 2 hours, the second time for 1.5 hours, filter, combine the filtrate, concentrate to a r...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating Parkinson's disease. The pharmaceutical composition consists of active ingredients and medically acceptable auxiliary materials, and is characterized in that the active ingredients consist of the following components in percentage by weight: rhizoma acori graminei volatile oil extracted from rhizoma acori graminei accounting for 25-45 percent and tortoise plastron water extract extracted from tortoise plastron accounting for55-75 percent. By adopting the pharmaceutical composition, neurological integrals of Parkinson's model rats can be obviously improved, the content of monoamine neurotransmitters in rat brains is increased, reduction of tyrosine hydroxylase in brain is inhibited, and the effect of preventing and treating the Parkinson's disease is obvious.

Description

Field of invention: [0001] The present invention relates to medical preparations, in particular to medical preparations containing raw materials with unknown structures. technical background: [0002] Parkinson's disease (PD) is a neurodegenerative disease that endangers the physical and mental health of the elderly. With the aging of the population, the incidence rate has increased significantly, which has become one of the most serious issues facing geriatric medicine. The survey shows that there are more than 1.7 million PD patients among the Chinese over the age of 55, and the prevalence rate is 1%. The national PD patients are about 5-7 million. Parkinson's disease, also known as parkinsonism, is clinically characterized by extrapyramidal movement disorders, manifested as slow movement, resting tremor, and rigid autonomic dysfunction and dementia. The pathological changes are manifested as the formation of Lewy bodies in residual dopamine neurons, gliocyte hyperplasia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/16A61K35/56A61K35/586
Inventor 方永奇张升方若鸣李翎
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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