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Biomarker of male infertility in unknown aetiology and application method of biomarker

A technology for biomarkers and male infertility, applied in the field of biomarkers, can solve problems such as difficulties, physical injury of patients, cumbersome semen sample sampling process, etc., and achieve the effect of convenient acquisition, accurate diagnosis, and avoidance of body damage.

Inactive Publication Date: 2014-05-07
INST OF URBAN ENVIRONMENT CHINESE ACAD OF SCI
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  • Abstract
  • Description
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Problems solved by technology

However, so far, there have been no reports of unexplained male infertility
In addition, the tissue sections required for diagnosis often cause certain damage to the patient's body, and the sampling process of semen samples is cumbersome and difficult, and may even be rejected by some patients due to its particularity. Therefore, the discovery of biomarkers in body fluids It is extremely important and urgent to develop simple and non-invasive detection methods

Method used

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  • Biomarker of male infertility in unknown aetiology and application method of biomarker
  • Biomarker of male infertility in unknown aetiology and application method of biomarker
  • Biomarker of male infertility in unknown aetiology and application method of biomarker

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Embodiment

[0036] sample collection

[0037] Urine samples were obtained from 71 patients with unexplained male infertility and 47 normal healthy male controls. In this paper, the male infertility patients refer to the fact that the male infertility patients are still infertile after more than one year of normal sexual life without contraceptive measures, but their spouses are evaluated as having normal reproductive function by clinical examination. Moreover, the routine semen examination indicators of these patients were all normal, and the set standards were semen volume ≥ 1.5 mL, sperm density ≥ 15×10 6 / mL, total sperm motility (%) ≥ 40, forward motility sperm rate (%) ≥ 32, vitality (%) ≥ 58. Normal controls were males who had given birth to their spouses within 3 months. All urine samples were collected in the Affiliated Hospital of Nanjing Medical University, and all subjects signed written informed consent.

[0038] urine preparation

[0039] Before analysis, dissolve the urin...

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Abstract

The invention provides a method for diagnosing male infertility in unknown aetiology and relates to an analytical test of a body fluid sample. In certain aspects, a biomarker for indicating male infertility in unknown aetiology is included; a method for identifying and detecting the biomarker is included; a kit for diagnosing or detecting male infertility in unknown aetiology is also included. According to the diagnosing method, the simple, accurate and non-invasive diagnosis of male infertility in unknown aetiology can be realized.

Description

technical field [0001] The present invention relates to biomarkers, in particular to biomarkers of unexplained male infertility, including methods for identifying and screening biomarkers of unexplained male infertility, including methods for detecting these biomarkers The method also includes a kit for diagnosing or detecting unexplained male infertility. Background technique [0002] According to the prediction of the World Health Organization, in this century, infertility will become the third largest disease after tumors and cardiovascular and cerebrovascular diseases. The incidence of infertility in married couples is 10-20%, the proportion of infertility caused by male factors is about 50%, and in male infertility patients, 50% is caused by spermatogenesis Oligospermia, asthenospermia and teratospermia caused by abnormal process. According to the research results of the Population and Family Planning Commission of my country, the semen quality of Chinese men is decli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N33/543
Inventor 张洁木晓丽申河清
Owner INST OF URBAN ENVIRONMENT CHINESE ACAD OF SCI
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