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Application of cyclic dipeptide C2 in phellinus igniarius to resisting H5N1 avian influenza virus

A technology of Phylophorus spp. and cyclic dipeptides, applied in antiviral agents, applications, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2014-05-28
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] A cyclic dipeptide has many important physiological activities such as antibacterial, so far, no report has been reported that has anti-influenza virus activity

Method used

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  • Application of cyclic dipeptide C2 in phellinus igniarius to resisting H5N1 avian influenza virus

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0037] (1) The fermentation medium formula is in grams / 100 milliliters:

[0038] Corn Starch 1% Glucose 1%

[0039] Peptone 0.1% Yeast Extract 0.1%

[0040] Magnesium sulfate 0.1% Potassium dihydrogen phosphate 0.01%

[0041] (2) Inoculate the Phyloporus spp. strains into the Erlenmeyer flask with the liquid medium in a conventional method, with a temperature of 25° C., a shaking flask rotation speed of 110 r / min, and pH 7 conditions, and vibrate for 7 days; cultivate When the pH value drops to 3, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, stir at a temperature of 25°C, a fermenter pressure of 0.1 kg / cm2, a pH of 3, and an air flow of 0.5-1.1vvm. Under the condition of a speed of 100 r / min, after culturing for 7 days, the crude extract of Pheronotus can be prepared by using the whole liquid fermented with the mycelia of Ph.

[0042] (3) Take ...

example 2

[0053] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0054] (1) The fermentation medium formula is in grams / 100 milliliters:

[0055] Corn Starch 3% Glucose 2%

[0056] Peptone 0.5% Yeast Extract 0.5%

[0057] Magnesium sulfate 0.5% Potassium dihydrogen phosphate 0.05%

[0058] (2) Inoculate the Phylophorus spp. strains into the Erlenmeyer flask with liquid medium in a conventional manner, with a temperature of 30° C., a shaker flask rotation speed of 180 r / min, and pH6 conditions, and vibrate for 15 days; during the cultivation When the pH value drops to 2.5, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, with a temperature of 30°C, a fermenter pressure of 0.2 kg / cm2, a pH of 3, an air flow of 0.5-1.1vvm, and a stirring speed Under the condition of 180 rev / min, after culturing for 15 days, the crude extract of Pheronotus can be prepared by using the fermented whole solution of Phyloporea mycelium. ...

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Abstract

The invention discloses a cyclic dipeptide C2 with an avian influenza-resisting activity, which is separated from fermentation broth and fruiting bodies of phellinus igniarius (LexFr) Quel (phellinus linteus (BerketCurt) Teng, phellinus baumii and phellinus hartigii (AlleschetSchnabl) Imaz). The invention firstly discloses a new activity of the cyclic dipeptide and proves that the cyclic dipeptide has an avian influenza-resisting action. Compared with the application of a general compound, the method has the advantages that the special new activity of the cyclic dipeptide is found, and the cyclic dipeptide has the action of resisting the avian influenza virus.

Description

technical field [0001] The present invention relates to a method for extracting and preparing active substances from Phylonotus spp., which is resistant to avian influenza H5N1 virus, especially the S. General Microbiology Center of the Preservation Management Committee", the deposit number is CGMCC No.8108, the taxonomic name is Phellinus igniarius, and the deposit address is No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences. Background technique [0002] Cyclic peptides usually referred to in biology refer to compounds formed by amino acid peptide bonds. In phytochemistry, this concept is expanded to a class of compounds formed by amide bonds, so the scope is expanded to include organic amines and macrocycles. Alkaloids are divided into cyclic peptides and linear peptides according to whether they form a ring or not. The reported cyclic peptide compounds have various biological activities, including anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4985A61P31/16C07D487/04A01G1/04
Inventor 赵晨宋爱荣孔超黄芳杨松
Owner QINGDAO AGRI UNIV
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