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Novel application of rhodioloside in resisting depression

A salidroside, antidepressant technology, applied in medical preparations containing active ingredients, organic active ingredients, nervous system diseases, etc.

Inactive Publication Date: 2014-07-09
NANJING HEAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention relates to the role and efficacy of salidroside in antidepressant, and no relevant reports have been seen

Method used

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  • Novel application of rhodioloside in resisting depression
  • Novel application of rhodioloside in resisting depression
  • Novel application of rhodioloside in resisting depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] configuration of salidroside liquid

[0018] Name: Synthetic Salidroside

[0019] Provider: Second Military Medical University, Shanghai.

[0020] Salidroside was dissolved in 0.9% saline to prepare 2.4mg / ml and 1.2mg / ml.

Embodiment 2

[0021] Effect of salidroside on lipopolysaccharide-induced acute depression mice

[0022] 1. Protective effect of salidroside on lipopolysaccharide-induced acute depression in mice

[0023] 1.1 Test method

[0024] 1.1.1 Test grouping and modeling

[0025] Take 60 healthy ICR mice, half male and half male, fasted for 12 hours, and drink water freely. They were randomly divided into 5 groups according to body weight, 12 rats in each group, which were control group, model group, fluoxetine (FLU) group, salidroside (Sal) high-dose and low-dose groups. Fluoxetine group (FLU, 20mg / kg), salidroside high and low dose groups (Sal, 24mg / kg, 12mg / kg). Except for the control group and the model group, the other groups were administered by intragastric administration for 7 days. One hour after administration on the seventh day, lipopolysaccharide (LPS, 0.5 mg / kg) was intraperitoneally injected into each group except the control group to establish a model.

[0026] 1.1.2 Index measur...

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Abstract

The invention relates to a novel application of an effective component rhodioloside of a plant rhodiola rosea. Integral animal experiment researches indicate that rhodioloside has a certain protective effect on experimental depression, and the action mechanism of the rhodioloside is possibly related to inflammation reaction inhibition (the levels of inflammatory factors IL-6 (interleukin-6) and TNF-alpha (tumor necrosis factor-alpha) in serum can be reduced), change of monoaminergic reaction in the brain (the content of neurotransmitter serotonin and noradrenaline in the brain can be increased), increase of expression of brain-derived neurotrophic factor (BDNF) in the brain, and the like. Therefore, the rhodioloside has an application prospect of development of anti-depression medicines.

Description

technical field [0001] The invention relates to a new application of salidroside, an active ingredient of the traditional Chinese medicine rhodiola rosea, in antidepressant aspect. Background technique [0002] Depression is characterized by persistent low mood and cognitive dysfunction, including restlessness, anhedonia, sleep disturbance, guilt, and recurrent suicidal thoughts. The main reason is that the level of specific neurotransmitters such as central norepinephrine, serotonin, and dopamine is too low and the receptor function is low, which has the characteristics of high incidence and wide age of onset. Depression not only brings patients Mental loss, but also a heavy financial burden on patients. As the pace of life in modern cities continues to accelerate, people are under increasing pressure, and the incidence of depression is also increasing year by year. At present, depression has become a mental disease that seriously endangers human physical and mental health...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P25/24
Inventor 何文捷朱凌鹏王静靳荣光
Owner NANJING HEAN MEDICAL TECH
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