Online detection method for double-effect concentration process of danhong injection
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A Danhong injection, double-effect concentration technology, applied in measuring devices, weighing by removing certain components, and conducting material analysis by optical means, etc., to achieve the effect of improving the level of quality control and stable product quality
Active Publication Date: 2014-07-09
ZHEJIANG UNIV +1
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Embodiment 1
[0048] Example 1 (Building a Global Model Using All Concentrate Samples)
[0049] 1. Design of near-infrared on-line detection device
[0050] see figure 1 The near-infrared on-line detection device includes a first valve 1, a second valve 2, a third valve 3, a fourth valve 4, a first-effect heating chamber 5 of the concentration equipment, a first-effect evaporation chamber 6 of the concentration equipment, and a second-effect heating chamber 5 of the concentration equipment ', concentration equipment second-effect evaporation chamber 6', circulation main pipe bypass 7, miniature magnetic drive gear pump 8, filter 9, flow cell 10, optical fiber probe 11, sampling tube 12, near-infrared spectrometer 13, one-effect circulation main pipe 14 , two-effect circulation main pipe 14' and steam pipeline; the first-effect heating chamber 5 of the concentration equipment is connected to the first-effect evaporation chamber 6 of the concentration equipment through the one-effect circul...
Embodiment 2
[0076] According to the method of Example 1, the difference is that the concentrated solution samples are divided into high and low concentrations by using the principal component analysis method, and local models of each quality control index are respectively established according to the categories.
[0077] 1. Spectral Principal Component Analysis
[0078] Perform principal component analysis on the collected 176 concentrated liquid samples, see the figure, the first principal component score of the high-density sample is higher, the first principal component value of the low-density sample is lower, and the first principal component score is used A value of 0.3 was used as a boundary, and high and low concentration (density) samples were divided into two categories. The above results indicate that, for samples with a large concentration span, segmental modeling may obtain better predictive ability than global modeling.
[0079] 2. Partial least squares regression method ...
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Abstract
The invention provides an online detection method for a double-effect concentration process of danhong injection. The method comprises the following steps: acquiring near infrared transmittance spectroscopy of danhong injection concentrate online by arranging a near infrared online detection device and collecting a concentrate sample; respectively measuring various pieces of quality control index information of the concentrate sample by a drying weighing method and high-performance liquid chromatography; removing abnormal spectrums; selecting a near infrared spectroscopy modeling waveband and a preprocessing method; establishing various quality control index quantitative models by a multivariate calibration algorithm; investigating the performance of the models by adopting various model evaluation indexes; online analyzing the variation trend of each quality control index in the concentration process by using the established models. According to the method, a near infrared online analysis technology is introduced into the concentration process of the danhong injection, so that the real-time monitoring of each quality control index (tanshinol, protocatechualdehyde, hydroxysafflor yellow A, rosmarinic acid, salvia acid B and moisture content) can be realized, the improvement on the quality control level in the danhong injection concentration process is facilitated, and the stable and reliable product quality is fully guaranteed.
Description
technical field [0001] The invention belongs to the field of near-infrared on-line detection, in particular to an on-line detection method for the double-effect concentration process of Danhong injection. Background technique [0002] Danhong Injection is my country's first patented Chinese patent medicine that quickly solves the insufficient blood supply of the whole body organs and ischemic infarct diseases. Salvia miltiorrhiza has the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain, and is one of the widely used traditional Chinese medicines in clinical practice. The water-soluble components isolated from Salvia miltiorrhiza include Danshensu, protocatechualdehyde, and salvianolic acid B. Safflower has the effect of promoting blood circulation and dredging collaterals, and contains two kinds of pigments, yellow and red. The active ingredients are mainly concentrated in water-soluble safflower yellow, such as hydroxy safflow...
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