Cancer risk stratification biomarkers, their applications, and cancer risk stratification devices
A cancer risk stratification and biomarker technology, applied in measuring devices, analytical materials, instruments, etc., can solve the problem of inability to accurately predict the risk of cancer metastasis in lymph node patients
Active Publication Date: 2016-03-23
深圳灵赋拓普生物科技有限公司
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[0003] The technical problem to be solved by the present invention is to provide a biomarker for cancer risk stratification in view of the defect that the prior art cancer overall survival prediction method cannot accurately predict the risk of cancer metastasis in patients with incomplete lymph node dissection when the lymph node dissection is insufficient. Drug, its application and cancer risk stratification device, which can accurately predict the risk of cancer metastasis in patients with incomplete lymph node dissection to guide further postoperative management of cancer
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[0033] PAK1 is a kinase that can regulate downstream signaling events, including cytoskeletal reorganization, cell motility, and epithelial-mesenchymal transition. Encouraging evidence suggests that many tumors respond to PAK1 inhibitors. Our study found that p21-activated protein kinase 1 (PAK1) is used as a prognostic biomarker, and its overexpression in GEJA is associated with poor prognosis. In order to determine the clinical application of a biomarker to supplement and improve the inaccuracy caused by incomplete lymph node dissection of GEJA's TNM staging; we tested whether PAK1 expression in primary cancers can predict lymph node metastasis. In addition, we analyzed matched pathological samples of primary GEJA and LN to study whether PAK1 expression in primary cancer can predict PAK1 levels in lymph nodes, and whether PAK1 is an independent predictor of GEJA lymph node metastasis and tumor-related clinical outcomes. Based on the above research, we have developed a cancer...
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The invention relates to a cancer risk stratification biomarker, an application thereof, and a cancer risk stratification device. The cancer risk stratification device comprises: a PAK1 used as a cancer risk stratification biomarker; an immunohistochemical detection kit for immunostaining the PAK1 and detecting the protein expression of the PAK1; and a risk stratification module for dividing pathological samples of the PAK1 into a PAK1 high expression group and a PAK1 low expression group based on the protein expression of the PAK1. With the cancer risk stratification biomarker, its application, and the cancer risk stratification device of the invention, cancer patients can be stratified individually by using the PAK1, and the risk of cancer metastasis for cancer patients can be predicted accurately. The biomarker and the device of the invention can be used for predicting prognosis of tumor patients, then stratifying risk degrees of the patients, and guiding the design of individualized treatment schemes of postoperative cancer patients.
Description
Technical field [0001] The invention relates to the field of cancer risk stratification, and more specifically to a cancer risk stratification biomarker, its application and a cancer risk stratification device. Background technique [0002] The gastroesophageal junction is the transition zone between the esophagus and the stomach. The gastroesophageal junction consists of the distal esophagus, the cardia and the proximal gastric tube. The incidence of gastroesophageal junction adenocarcinoma (Adenocarcinomaofesophago-gastricjunction, GEJA) is increasing, and the prognosis is poor. Siewert and Stein proposed the morphological / anatomical classification of GEJA (type I: distal esophageal adenocarcinoma; type II: true gastroesophageal junction cancer; and type III: gastric cancer infiltrating the distal esophagus) to guide the treatment strategy of this cancer . American Joint Committee on Cancer (American Joint Committee on Cancer, AJCC) TNM staging is often used to guide clinici...
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IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 张灏
Owner 深圳灵赋拓普生物科技有限公司