Cancer risk stratification biomarker, application thereof and cancer risk stratification device
A cancer risk stratification and biomarker technology, applied in measuring devices, analytical materials, instruments, etc., can solve the problem of inability to accurately predict the risk of cancer metastasis in lymph node patients
Active Publication Date: 2014-07-09
深圳灵赋拓普生物科技有限公司
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[0003] The technical problem to be solved by the present invention is to provide a biomarker for cancer risk stratification in view of the defect that the prior art cancer overall survival prediction method cannot accurately predict the risk of cancer metastasis in patients with incomplete lymph node dissection when the lymph node dissection is insufficient. Drug, its application and cancer risk stratification device, which can accurately predict the risk of cancer metastasis in patients with incomplete lymph node dissection to guide further postoperative management of cancer
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[0033] PAK1 is a kinase that regulates downstream signaling events, including cytoskeletal reorganization, cell motility, and epithelial-mesenchymal transition. Encouraging evidence suggests that many tumors respond to PAK1 inhibitors. Our study identified p21-activated protein kinase 1 (PAK1) as a prognostic biomarker and its overexpression was associated with poor prognosis in GEJA. To identify a biomarker that can be used clinically to complement and improve the inaccuracy of GEJA's TNM staging in incomplete lymph node dissection; we examined whether PAK1 expression in primary cancers could predict lymph node metastasis. Furthermore, we analyzed paired pathological samples of primary GEJA and LN to investigate whether PAK1 expression in primary cancer could predict PAK1 levels in lymph nodes and whether PAK1 was an independent predictor of lymph node metastasis and tumor-related clinical outcomes in GEJA. Based on the above research, we have developed a cancer risk stratif...
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The invention relates to a cancer risk stratification biomarker, an application thereof, and a cancer risk stratification device. The cancer risk stratification device comprises: a PAK1 used as a cancer risk stratification biomarker; an immunohistochemical detection kit for immunostaining the PAK1 and detecting the protein expression of the PAK1; and a risk stratification module for dividing pathological samples of the PAK1 into a PAK1 high expression group and a PAK1 low expression group based on the protein expression of the PAK1. With the cancer risk stratification biomarker, its application, and the cancer risk stratification device of the invention, cancer patients can be stratified individually by using the PAK1, and the risk of cancer metastasis for cancer patients can be predicted accurately. The biomarker and the device of the invention can be used for predicting prognosis of tumor patients, then stratifying risk degrees of the patients, and guiding the design of individualized treatment schemes of postoperative cancer patients.
Description
technical field [0001] The present invention relates to the field of cancer risk stratification, more specifically, to a cancer risk stratification biomarker, its application and a cancer risk stratification device. Background technique [0002] The gastroesophageal junction is the transition zone between the esophagus and the stomach. The gastroesophageal junction consists of the distal esophagus, cardia, and proximal gastric tube. The incidence of gastroesophageal junction adenocarcinoma (Adenocarcinoma of esophago-gastric junction, GEJA) is increasing, and the prognosis is poor. Siewert and Stein proposed a morphological / anatomical classification of GEJA (type I: adenocarcinoma of the distal esophagus; type II: true gastroesophageal junction carcinoma; and type III: gastric cancer with invasion of the distal esophagus) to guide treatment strategies for this cancer . American Joint Committee on Cancer (AJCC) TNM staging is commonly used to guide clinicians in prognostic...
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IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 张灏
Owner 深圳灵赋拓普生物科技有限公司