Method for preparing nine-flavor notopterygium dropping pills

A technology of notopterygium and dripping pills, which is applied in the field of preparation of Jiuwei notopterygium dripping pills, which can solve the problems of less application in large-scale industrial production and high cost of supercritical extraction, and achieve the effects of ensuring drug efficacy, stable quality and high bioavailability

Inactive Publication Date: 2014-07-16
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention uses supercritical extraction to extract volatile oil, but the cost of supercritical extraction is high, and it is rarely used in large-scale industrial production

Method used

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  • Method for preparing nine-flavor notopterygium dropping pills
  • Method for preparing nine-flavor notopterygium dropping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 A preparation method of Jiuwei notopterygium dripping pills, comprising the following steps:

[0057] (1) Select notopterygium 150g, Fangfeng 150g, atractylodes atractylodes 150g, asarum 50g, chuanxiong 100g, angelica dahurica 100g, scutellaria baicalensis 100g, licorice 100g, rehmannia glutinosa 100g, respectively, after cleaning, drying, and crushing at room temperature into 24 mesh coarse powder of medicinal materials.

[0058] (2) Mix Notopterygium, Fangfeng, Cangzhu, Asarum, and Chuanxiong obtained in step (1) to obtain a mixture; add distilled water 8 times its mass to the mixture, heat and distill at 100°C for 4 hours, and obtain volatile oil and distilled solution respectively.

[0059] (3) Extract the volatile oil obtained in step (2) with 30°C petroleum ether for 3 times, combine the petroleum ether liquid, volatilize the petroleum ether at 30°C to a small volume, then add anhydrous sodium sulfate for dehydration, and filter and volatilize the p...

Embodiment 2

[0069] Example 2 A preparation method of Jiuwei notopterygium dripping pills, comprising the following steps:

[0070] (1) Select notopterygium 150g, Fangfeng 150g, Atractylodes atractylodes 150g, Asarum 50g, Chuanxiong 100g, Angelica dahurica 100g, Scutellaria baicalensis 100g, licorice 100g, and Rehmannia glutinosa 100g, respectively, after cleaning, drying, and crushing into 50-mesh medicinal material coarse powder at room temperature.

[0071] (2) Mix Notopterygium, Fangfeng, Cangzhu, Asarum, and Chuanxiong obtained in step (1) to obtain a mixture; add distilled water 12 times its mass to the mixture, heat and distill at 90°C for 8 hours, and obtain volatile oil and distilled solution respectively.

[0072] (3) Extract the volatile oil obtained in step (2) with 60°C petroleum ether for 3 times, combine the petroleum ether liquid, volatilize the petroleum ether at 40°C to a small volume, then add anhydrous sodium sulfate for dehydration, and filter and volatilize the pe...

Embodiment 3

[0082] Example 3 A preparation method of Jiuwei notopterygium dripping pills, comprising the following steps:

[0083] (1) Select notopterygium 150g, Fangfeng 150g, Atractylodes atractylodes 150g, Asarum 50g, Chuanxiong 100g, Angelica dahurica 100g, Scutellaria baicalensis 100g, licorice 100g, and Rehmannia glutinosa 100g, respectively, after cleaning, drying, and crushing at room temperature into 35-mesh medicinal powder.

[0084] (2) Mix Notopterygium, Fangfeng, Atractylodes Rhizoma Atractylodis, Asarum, and Chuanxiong obtained in step (1) to obtain a mixture; add distilled water 10 times its mass to the mixture, heat and distill at 95° C. for 6 hours, and obtain volatile oil and distilled solution respectively.

[0085] (3) Extract the volatile oil obtained in step (2) with 45°C petroleum ether for 3 times, combine the petroleum ether liquid, volatilize the petroleum ether at 35°C to a small volume, then add anhydrous sodium sulfate for dehydration, and filter and vola...

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Abstract

The invention relates to a method for preparing a nine-flavor notopterygium dropping pill. The method comprises the following steps: (1) crushing the prescriptions of the nine-flavor notopterygium dropping pill to medicinal material crude powder; (2) mixing notopterygium root, divaricate saposhnikovia root, rhizoma atractylodis, asarum and ligusticum wallichii, and distilling to obtain volatile oil and a distilled solution, respectively; (3) preparing pure volatile oil; (4) preparing a volatile oil absolute ethyl alcohol solution; (5) adding distilled water into beta-cyclodextrin to prepare a saturated solution, and then adding the volatile oil absolute ethyl alcohol solution to prepare a volatile oil clathrate compound; (6) mixing radix angelicae with scutellaria baicalensis, and performing alcohol extraction to obtain a filtrate A; (7) performing vacuum concentrating on the filtrate A to obtain an extract A; (8) mixing licorice with radix rehmanniae, and adding water for decoration to obtain a filtrate B; (9) mixing the distilled solution with the filtrate B, and performing vacuum concentration and alcohol precipitation filtration to obtain a filtrate C; (10) performing vacuum concentrating on the filtrate C to obtain an extract C; (11) fusing polyethylene glycol, adding the volatile oil clathrate compound, the extract A and the extract to prepare dropping pills. The method provided by the invention is stable in quality and high in bioavailability.

Description

technical field [0001] The invention relates to a preparation method of dripping pills, in particular to a preparation method of Jiuwei notopterygium dripping pills. Background technique [0002] The prescription of Jiuwei notopterygium is derived from Zhang Yuanyuan's "This matter is difficult to know", mainly composed of notopterygium 150g, fangfeng 150g, atractylodes 150g, asarum 50g, chuanxiong 100g, angelica dahurica 100g, scutellaria baicalensis 100g, licorice 100g, rehmannia glutinosa 100g, mainly for exogenous wind-cold-dampness Evil, combined with interior heat syndrome, manifested in aversion to cold and fever, no sweat on the skin surface, headache and numbness, sore limbs, bitter mouth and slightly thirsty, white or yellowish tongue coating, and floating pulse. At present, the common Jiuwei notopterygium preparations in clinical practice include pills, granules, oral liquids, tablets, soft capsules, sprays, etc. [0003] Chinese patent ZL 200510057076.9, the pre...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/20A61K47/48A61P29/00
Inventor 张喜民张政邓月婷吴秀琴仲万春贾继禧
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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