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Polypeptides, polypeptide compositions, and polypeptide biological materials as well as their preparation methods and uses

A polypeptide composition and biomaterial technology, applied in the fields of polypeptides, polypeptide biomaterials, and polypeptide compositions, can solve the problem of poor hemostasis, the risk of infectious diseases of animal origin, high antigenicity, and inconvenient production and use of thrombin. problems, to avoid the risk of infectious diseases of animal and plant origin, reduce complications, good biodegradability and compatibility

Active Publication Date: 2018-04-24
四川芯意成科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production and use of thrombin are inconvenient, and its high antigenicity is also a limiting factor
[0014] In summary, the above-mentioned hemostatic materials have disadvantages such as poor hemostatic effect, dependence on the normal coagulation pathway of the body, and the risk of zoonotic infectious diseases. The characteristics of the proposed ideal local hemostatic material: efficient hemostatic effect; easy to use; good biocompatibility and safety; industrial production

Method used

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  • Polypeptides, polypeptide compositions, and polypeptide biological materials as well as their preparation methods and uses
  • Polypeptides, polypeptide compositions, and polypeptide biological materials as well as their preparation methods and uses
  • Polypeptides, polypeptide compositions, and polypeptide biological materials as well as their preparation methods and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A polypeptide whose amino acid sequence is shown in SEQ ID NO.1.

[0054] SEQ ID NO.1: Cys-Arg-Leu-Cys-Gly-Gly-Cys-Arg-Leu-Cys

Embodiment 2

[0056] A polypeptide whose amino acid sequence is shown in SEQ ID NO.2.

[0057] SEQ ID NO.2: Cys-Lys-Leu-Pro-Leu-Lys-Val-Gly-Gly-Ile-Arg-Glu-Cys

Embodiment 3

[0059] A polypeptide whose amino acid sequence is shown in SEQ ID NO.3.

[0060] SEQ ID NO. 3: Cys-Ile-Lys-Leu-Glu-Ile-Lys-Pro-Leu-Lys-Val-Pro

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PUM

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Abstract

The invention discloses a polypeptide, a polypeptide composition, a polypeptide biomaterial based on the polypeptide / polypeptide composition, and preparation methods and uses thereof. The polypeptide comprises anyone of amino acid sequences represented by SEQIDNO.1-7, and a sequence having at least 60% homology with anyone of amino acid sequences represented by SEQIDNO.1-7. The polypeptide composition comprises at least two sequences of the above sequences. The polypeptide biomaterial is a gel, and comprises the polypeptide or polypeptide composition, and a solvent capable of dissolving the polypeptide or polypeptide composition. Atomic force microscope observation results show that the polypeptide biomaterial forms a compact nanofiber mesh structure, and has the characteristics of fast bleeding stopping, use convenience, good safety and easy large-scale industrial production.

Description

technical field [0001] The invention relates to the field of hemostatic materials, in particular to a polypeptide, a polypeptide composition and a polypeptide biological material used in the field of hemostasis, as well as their preparation method and application. Background technique [0002] Although blood products are available, blood loss is still an important cause of morbidity and death. The statistics of local wars after World War II show that 30%-60% of the deaths are caused by severe blood loss. Effective hemostasis is the key to improving the wounded in wartime key to survival. In addition to wartime, effective hemostasis is also a necessary measure to reduce casualties in situations such as surgery, natural disasters, and emergencies. According to data from China Business Intelligence Network, in 2010, the number of surgical operations in my country reached 30 million. In addition to bleeding caused by surgery, the number of early deaths due to traumatic bleeding...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06C07K7/08C07K19/00A61L15/32A61L15/42A61L31/04A61L31/14A61L31/16
Inventor 唐成康蒲世凤
Owner 四川芯意成科技有限公司
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