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Quality detecting method for concentration process in horny goat weed extract production process

A technology of epimedium extract and quality detection method, which is applied in the field of medicine, can solve the problems of large consumption of drugs and reagents, lagging detection results, long detection time, etc., and achieve the effect of real-time online detection

Inactive Publication Date: 2014-10-01
GUANGZHOU HANFANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

If you want to further obtain the content of icariin, you need to use high-performance liquid chromatography. This method needs to consume a large amount of medicines and reagents, and the detection time is long, and the detection results are lagging behind. It cannot meet the requirements of modern large-scale production for effectiveness. and online quality control needs

Method used

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  • Quality detecting method for concentration process in horny goat weed extract production process
  • Quality detecting method for concentration process in horny goat weed extract production process
  • Quality detecting method for concentration process in horny goat weed extract production process

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Experimental program
Comparison scheme
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Embodiment 1

[0023] 1. Spectral probe installation:

[0024] Install the fluid sampler of the collection disc in the circulation pipeline of the concentration tank.

[0025] 2. Preparation of epimedium concentrated solution:

[0026] Put Epimedium 30kg / can into a multi-energy extraction tank, add water to extract 3 times, add 10 times the volume of water for the first extraction, add 10 times the volume of water for the second and third times, and boil for 1 to 2 hours each; The solution is coarsely passed through a 60-100 mesh sieve, cooled to 60°C, combined, and 500mL of Epimedium aqueous solution is added to a double-effect concentration tank, and concentrated under reduced pressure at 80°C to a density of 1.02-1.08g / L.

[0027] 3. Sampling method

[0028] During the concentration process, samples are taken every 5 minutes in the first half hour, and samples are taken every 2 minutes to the end of the concentration.

[0029] 4. Detection method of total flavonoids

[0030] Precisely...

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Abstract

The invention discloses a quality detecting method for concentration process in the horny goat weed extract production process. The quality detecting method comprises the following steps: (1) preparing a horny goat weed concentrate; (2) sampling: mounting a sampling valve on a circulating pipeline of a concentrating tank to sample, and recording sampling time, wherein the sampling scheme is that sampling is conducted every 2-5 min for 50 mL each time; (3) utilizing an AOTF (Acousto-Optic Tunable Filter) near infrared spectrometer to collect near infrared spectrums corresponding to spectrums; (4) detecting the total flavonoid content of the collected sample off-line through an ultraviolet spectrophotometry; (5) utilizing a mathematical metering software to correlate near infrared spectrum data and off-line test data, and establishing a calibration model. According to the invention, the near infrared spectroscopy is successfully applied to the production process of the traditional Chinese medicine, real-time on-line quality control of the production process of the traditional Chinese medicine is realized, and the real-time on-line detection of the total flavonoid content in the horny goat weed production process is realized.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to realize the online monitoring and quality control of the concentration process of the epimedium extract in the production process by using the AOTF near-infrared spectrum online detection technology. Background technique: [0002] Epimedium is a Berberidaceae plant with high medicinal value. Spicy in the mouth, sweet, warm. Return liver, kidney meridian, function with indications: invigorating kidney yang, strengthening muscles and bones, expelling rheumatism. The extract mainly contains flavonoids, lignans, alkaloids, and volatile oils. The evaluation of the epimedium extract is mainly based on the content of total flavonoids in it, and the detection of the content of total flavonoids is calculated by spectrophotometry. If you want to further obtain the content of icariin, you need to use high-performance liquid chromatography. This method needs to consume a large amount of medicines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3577G01N21/33
Inventor 许定舟李菁刘翠红杨丽李宇钟鸣
Owner GUANGZHOU HANFANG PHARMA
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