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A kind of method for extracting aconitine from the root of aconitum chinensis

A technology of high aconitine and high aconitum, applied in the direction of organic chemistry, etc., can solve the problems of large waste of production resources, low yield and high cost

Active Publication Date: 2016-09-28
CHANGSHA HUIRUI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, at present, the production resources of high uricine are wasteful, the yield is very low, and the cost is extremely high, resulting in expensive medicines, which cannot meet the needs of the people for medicines.

Method used

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  • A kind of method for extracting aconitine from the root of aconitum chinensis
  • A kind of method for extracting aconitine from the root of aconitum chinensis
  • A kind of method for extracting aconitine from the root of aconitum chinensis

Examples

Experimental program
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Effect test

example 1

[0013] Example 1: Take 50kg of Aconitum root, add 500L of 90% methanol solution, heat and reflux for extraction for 2 hours, collect the filtrate by filtration, add 300L of 90% methanol solution to heat and reflux for extraction for 2 hours. Collect the filtrate by filtration, combine the two extraction filtrates, recover the alcohol to obtain the alcohol extraction extract, dissolve the alcohol extraction extract in 1-5% hydrochloric acid, filter to obtain the acid solution, adjust the pH to 7.5- 8.0, there is a large amount of precipitation, and after standing still, filter the precipitation to obtain the crude product A of total alkaloids of high aconitum. Then adjust the pH value of the filtrate to 12-13 with alkali, filter after standing, remove the precipitate, extract the filtrate twice with chloroform, recycle the chloroform, and obtain the crude product B with the content of N-deacetylhoconine, and the crude product A and B were combined, dissolved in chloroform, and ...

example 2

[0014] Example 2: Take 500 kg of Aconitum root, add 500 L of 85% methanol solution, heat and reflux for extraction for 2 hours, filter and collect the filtrate, add 300 L of 85% methanol solution for heating and reflux for 2 hours to extract the dregs. Collect the filtrate by filtration, combine the two extraction filtrates, recover the alcohol to obtain the alcohol extraction extract, dissolve the alcohol extraction extract in 1-5% hydrochloric acid, filter to obtain the acid solution, adjust the pH to 9.5-11 with soda ash, and a large amount of precipitation occurs , after standing still, the precipitate was filtered to obtain the crude product of high aconitum total alkaloids. Dissolve the total alkaloids in methanol, wash with 1% activated carbon to decolorize, recover the methanol until the alcohol content is about 50%, cool down, let it stand for crystallization, filter the crystals, and obtain the crude product of urine. The purity of the coarse crystal is about 70%. (...

example 3

[0015] Example 3: Take 500kg of Aconitum root, add 5000L of 80% methanol solution, heat and reflux for extraction for 2 hours, filter and collect the filtrate, add 80% methanol solution to the dregs and add 3000L of 80% methanol solution for 2 hours and heat and reflux for extraction. Collect the filtrate by filtration, combine the two extraction filtrates, recover the alcohol to obtain the alcohol extraction extract, dissolve the alcohol extraction extract in 1-5% hydrochloric acid, filter to obtain the acid solution, adjust the pH to 7.5-8.0 with soda ash, a large amount of precipitation occurs, After standing still, the precipitate was filtered to obtain the crude product A of total alkaloids of aconitum. Then adjust the pH value of the filtrate to 12-13 with caustic soda, filter after standing, remove the precipitate, extract the filtrate twice with chloroform, recycle the chloroform, and obtain the crude product B with the content of N-deacetylhokinine, and the crude produ...

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Abstract

The invention discloses a method for extracting lappaconitine from aconitum sinomontanum plant roots. The method includes following steps: extracting aconitum sinomontanum total alkaloids through alkaloid conventional extraction technologies; directly carrying out an acetylation synthesis reaction to N-deacetyllappaconitine in the total alkaloids (wherein the N-deacetyllappaconitine is mainly generated from degradation of lappaconitine) without separation and purification; performing a structure modification process to convert the N-deacetyllappaconitine into lappaconitine; extracting content of the lappaconitine; and performing an extraction process, a separation process and a purification process to the lappaconitine through conventional extraction and separation technologies. By means of the method, production quality is improved, production yield is increased and production cost is reduced.

Description

technical field [0001] Biopharmaceuticals, plant extracts. Background technique [0002] Aconitine (also known as aconitine, Lappa-conitine, Lappa-conitine) is an alkaloid extracted from the root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. Synthesis of alkaloids and hydrobromic acid into homogenate hydrobromide. The hydrobromide salt of gaurine is the first new non-addictive analgesic drug in China, which is used to treat moderate and severe pain. Compared with pethidine, this product has the same analgesic effect, slightly slower onset time, and longer maintenance time; the analgesic effect is 7 times that of the antipyretic and analgesic drug aminopyrine. This product also has the effects of local anesthesia, cooling, antipyretic, anti-inflammatory and detumescence. [0003] (1α,14α,16β)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,-9triol 4-[2-(Acetamido)benzoate]hydrobromic acid salt monohydrate. [0004] At present, the extraction technology of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D221/22
CPCC07D221/22
Inventor 阳水刘毛东朱华新
Owner CHANGSHA HUIRUI BIO TECH