Application of salted indianmulberry root polysaccharide in preparation of functional food with effect of helping inhibit prostate cancer

A technology for Morinda officinalis polysaccharide and prostate cancer, which is applied in the field of polysaccharides to achieve the effects of stable and efficient process, simple process, high purity and activity

Active Publication Date: 2014-10-29
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no one has obtained polysaccharides from Morinda officinalis as a raw material, and used them to assist in the development of inhibition of prostate cancer

Method used

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  • Application of salted indianmulberry root polysaccharide in preparation of functional food with effect of helping inhibit prostate cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The Morinda officinalis polysaccharide in this example is prepared by the following method: take the raw material of Morinda officinalis, soak it in a saline concentration of 20.0% by mass for 45 minutes, and steam it under a pressure of 0.10 MPa Preparation 1.5 h, carry out salt preparation, Morinda officinalis polysaccharide after salt preparation, adopt boiling water to extract, when extracting for the first time, the consumption of water is 20 times of raw material total mass, boil 5 h; During the second extraction, water The amount of water used was 20 times the total mass of raw materials, boiled for 3 h; for the third extraction, the amount of water used was 10 times the total mass of raw materials, boiled for 2 h to filter, combined filtrates, and vacuum concentrated to about 1 / 10 of the original volume. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume (the same below) of 30% trichloroacetic acid (mass percent...

Embodiment 2

[0034] The Morinda officinalis polysaccharide in this example was prepared by the following method: take the raw material of Morinda officinalis, soak it in a saline concentration of 20.0% by mass for 60 minutes, steam it under a pressure of 0.11 MPa for 1 .5 h, carry out salting, the Morinda officinalis polysaccharide after salting, adopt boiling water to extract, when extracting for the first time, the consumption of water is 15 times of the total mass of Morinda officinalis raw material, boil 5 h; When extracting for the second time, The amount of water used was 15 times the total mass of Morinda officinalis raw materials, and boiled for 3 hours; for the third extraction, the amount of water used was 10 times the total mass of Morinda officinalis raw materials, boiled for 3 hours, filtered, and the filtrates were combined and concentrated in vacuo. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume of 25% trichloroacetic ac...

Embodiment 3

[0036] The Morinda officinalis polysaccharide in this example is prepared by the following method: take the raw material of Morinda officinalis, soak it in a saline concentration of 20.0% by mass for 50 minutes, and steam it under a pressure of 0.12 MPa 1. 5 h, salt processing. After salting the Morinda officinalis polysaccharide, when extracting it for the first time, the amount of water used was 10 times the total mass of the raw material of Morinda officinalis, and boiled for 3 h; when it was extracted for the second time, the amount of water used was 20 times the total mass of the raw material times, boiled for 3 h; for the third extraction, the amount of water used was 10 times the total mass of Morinda officinalis raw materials, boiled for 5 h and filtered, combined the filtrates, concentrated in vacuo, and treated the concentrate with trichloroacetic acid for protein removal, adding the same 15% trichloroacetic acid (mass percentage) by volume, after a treatment time of...

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Abstract

The invention discloses application of salted indianmulberry root polysaccharide in preparation of functional food with the effect of helping inhibit prostate cancer. Salted indianmulberry root polysaccharide is preferably prepared by the following method: processing indianmulberry root used as a raw material with salt, extracting with boiling water, removing protein, dialyzing and carrying out ethanol treatment. The indianmulberry root polysaccharide has the function of adjusting the tumor microenvironment. The salted indianmulberry root polysaccharide can adjust the tumor microenvironment through multiple ways such as inhabitation of tumor angiogenesis, inhabitation of immunity and inhabitation of fibroblast growth of the prostate cancer, so that the salted indianmulberry root polysaccharide has a good effect of helping inhibit prostate tumors.

Description

technical field [0001] The invention belongs to the technical field of polysaccharides, and in particular relates to the application of salt-made Morinda officinalis polysaccharides in the preparation of functional foods with the effect of assisting in inhibiting prostate cancer. Background technique [0002] Malignant tumors are currently a serious disease that endangers human health. Chemotherapy is one of the main methods used in the systemic treatment of malignant tumors. However, most anti-tumor chemical drugs also seriously damage normal cells while killing tumor cells. Therefore, looking for Anticancer drugs with high efficiency and low toxicity are of great significance. In recent years, studies have found that polysaccharides have significant anti-tumor activity and have relatively small toxic and side effects on the human body. The research on the biological activity of polysaccharides has become a hot spot for experts and scholars at home and abroad in the medical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A61K31/715A61P35/00
CPCA23L29/30A23V2002/00C08B37/0003A23V2300/14A23V2250/21A23V2250/51A23V2200/308
Inventor 胡明华梁明王培培马方励
Owner INFINITUS (CHINA) CO LTD
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