Cordyceps militaris microcapsules, preparation and preparation method thereof

A technology of Cordyceps militaris superfine powder and Cordyceps militaris, which is applied in the direction of microcapsules, capsule delivery, anti-inflammatory agents, etc. It can solve the problems of limiting the practical application of microcapsule technology, difficult to ensure product safety, and easy deliquescent hardening of superfine powder, and achieves The product has strong practicability and effectiveness, is conducive to absorption and utilization, and enhances the effect of product safety

Active Publication Date: 2017-08-29
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for Cordyceps militaris, there are two obvious deficiencies in the ultrafine powder: the one, the ultrafine powder is easy to deliquesce and harden, has poor fluidity, poor compressibility, is not easy to be pressed into shape, and the whole herb powder is difficult to prepare; the other is the poor stability in the micropowder The active ingredients are more likely to decompose and deteriorate, resulting in a sharp decrease in its stability and seriously affecting product quality
The existing microcapsule technology needs to add a variety of reagents (coagulants, electrolytes, surfactants, non-aqueous solvents, etc.), product safety is not easy to ensure, and is accompanied by a complicated process, resulting in high product costs and poor reliability, which greatly limits Practical application of microencapsulation technology
Preparation of microcapsules and microcapsule preparation products with Cordyceps militaris superfine powder has not been reported yet

Method used

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  • Cordyceps militaris microcapsules, preparation and preparation method thereof
  • Cordyceps militaris microcapsules, preparation and preparation method thereof
  • Cordyceps militaris microcapsules, preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 300g of pregelatinized starch, slowly add 1000ml of pure water pre-cooled at 15°C under stirring, after the system is uniformly dissolved, add cold water until the content of pregelatinized starch reaches 20%. 1000g Cordyceps militaris superfine powder is slowly added to the cold solution in batches under stirring, fully stirred evenly at ≤15°C, and then spread on a tray (material thickness 1cm) and placed in a 50°C oven. water, dried under reduced pressure, and sieved to obtain 1236g of Cordyceps militaris microcapsule powder.

Embodiment 2

[0034] Substantially the same as Example 1, but adopt pregelatinized starch 200g, add cold water to be mixed with 15% solution and 1000g Cordyceps militaris superfine powder and prepare 1127g Cordyceps militaris microcapsule powder.

Embodiment 3

[0036] Substantially the same as Example 1, but adopt pregelatinized starch 100g, add cold water to be mixed with 10% solution and 1000g Cordyceps militaris superfine powder and prepare 1006g Cordyceps militaris microcapsule powder.

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Abstract

The invention discloses cordyceps militaris microcapsules, a cordyceps militaris microcapsule preparation and a preparation method thereof and provides a cordyceps militaris microcapsule. The microcapsule is formed by taking cordyceps militaris ultra-fine powder as a capsule core and taking pregelatinized starch as a capsule material, wherein a mass ratio of the cordyceps militaris to the pregelatinized starch is 10:(1-3). The preparation method comprises the following steps: mixing and dispersing the capsule core and the capsule material in a water system of 15 DEG C, raising the temperature, preserving the temperature, removing water, drying and screening, thereby preparing the microcapsules. The invention also provides a cordyceps militaris microcapsule preparation which is prepared by adding microcrystalline cellulose, sodium carboxymethylcellulose, sodium carboxymethyl starch and magnesium stearate into the cordyceps militaris microcapsules according to a conventional preparation method. The cordyceps militaris microcapsules have the characteristics of high stability, long product quality guarantee period, high content of active ingredients, high component dissolution rate, good taste and convenience in use.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a microcapsule of Cordyceps militaris, a preparation and a preparation method thereof. Background technique [0002] Cordyceps militaris, also known as Cordyceps militaris and Cordyceps militaris, is a fungus of the genus Cordyceps. Its pharmacology, medicinal chemistry and clinical experiments prove that Cordyceps militaris can be completely used as a substitute of Cordyceps sinensis. Cordyceps sinensis is as famous as ginseng and velvet antler, and is well-known both at home and abroad as the three traditional Chinese tonics. According to traditional Chinese medicine, Cordyceps enters the lung and kidney meridians, and is the only one that treats kidney deficiency, impotence, nocturnal emission, waist and knee pain, weakness after illness, spontaneous sweating, etc. A traditional Chinese medicine that balances and regulates yin and yang at the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/068A61P13/12A61P15/10A61P29/00A61P15/08
Inventor 任勇高茜袁放张敏敏
Owner NANJING NORMAL UNIVERSITY
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