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Staged acting antibacterial hydrogel dressing and preparation method thereof

A hydrogel, staged technology, applied in the field of medicine, can solve the problems of waterproofing and insufficient wound healing

Active Publication Date: 2014-12-24
ARNOKANG NINGXIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current hydrogel dressings are single-layer or double-layer, and the double-layer has an antibacterial layer and a water-absorbing layer. The existing hydrogel dressings are insufficient in waterproofing and promoting wound healing, and only a small part has antibacterial effects.

Method used

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  • Staged acting antibacterial hydrogel dressing and preparation method thereof
  • Staged acting antibacterial hydrogel dressing and preparation method thereof
  • Staged acting antibacterial hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A preparation method for staged antibacterial hydrogel dressing, comprising the steps of:

[0045] 1) Preparation of antibacterial layer: preparation of nano-silver / sodium polyacrylate mixed colloid

[0046] Dilute the synthesized nano-silver into a 100mL volumetric flask with a concentration of 100mg / L, weigh 2.0g of sodium polyacrylate and add it to the nano-silver solution, and stir while adding until the colloid is completely formed.

[0047] Put it into an oven at 60°C and dry it under vacuum for 20 minutes until an antibacterial layer with proper viscosity is obtained.

[0048] 2) Preparation of water absorption and sustained release layer: preparation of mixed glues such as sodium polyacrylate, pearl powder, bezoar, and carboxymethyl chitosan

[0049] Weigh 0.2 g of pearls and 0.2 g of bezoar and dissolve them in 100 mL of carboxymethyl chitosan solution, slowly add 2 g of sodium polyacrylate into the solution, and stir while adding until a transparent colloid i...

Embodiment 2

[0056] The preparation method of the present embodiment is basically the same as that of Example 1, except that:

[0057] In the step 1), the concentration of the nano-silver solution is 150 mg / L, and the dosage of the sodium polyacrylate is 1.5 g; the drying temperature is 50° C., and the drying time is 30 minutes.

[0058] In the step 2), 1.5 g of sodium polyacrylate, 0.5 g of pearl powder, and 0.3 g of bezoar are used, and the drying temperature is 70° C., and the drying time is 5 hours.

[0059] In said step 3), 1.5 g of polyvinyl butyral powder.

[0060] In the step 4), the drying is to put the mixed layer into a 40° C. oven and bake continuously for 5 hours.

Embodiment 3

[0062] The preparation method of the present embodiment is basically the same as that of Example 1, except that:

[0063] In the step 1), the concentration of the nano-silver solution is 200mg / L, the dosage of the sodium polyacrylate is 1.8g; the drying temperature is 70°C, and the drying time is 15 minutes.

[0064] In the step 2), 1.8 g of sodium polyacrylate, 0.3 g of pearl powder, and 0.5 g of bezoar are used, and the drying temperature is 50° C., and the drying time is 6 h.

[0065] In said step 3), 1.0 g of polyvinyl butyral powder.

[0066] In the step 4), the drying is to put the mixed layer into an oven at 50° C. and bake continuously for 3 hours.

[0067] The staged action antibacterial hydrogel dressing provided by the present invention has the characteristics of waterproof (reducing secondary trauma), staged effect ( antibacterial, promoting wound healing effect is remarkable) characteristics.

[0068] When it is applied to the diabetic wound infection model, th...

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Abstract

The invention discloses a staged acting antibacterial hydrogel dressing and a preparation method thereof. The method comprises the following steps: preparing an antibacterial layer, namely adding sodium polyacrylate into a nano-silver solution, stirring to form a colloid, and drying the colloid to obtain the antibacterial layer; preparing a water absorbing and sustained release layer, namely dissolving pearl powder and bezoar in a carboxymethyl chitosan solution to obtain a mixed solution, slowly adding sodium polyacrylate into the mixed solution, and stirring along with adding until a transparent colloid is formed; preparing a waterproof breathable layer, namely adding polyvinyl butyral powder into an absolute ethanol solution, and dissolving to obtain a transparent liquid; and assembling, namely pouring the transparent liquid into a plate which is 1.5-2.5mm thick, covering a non-woven fabric, spreading the transparent colloid of the water absorbing and sustained release layer on the non-woven fabric to obtain a mixed layer, baking the mixed layer to adhere the transparent colloid and the transparent liquid together, and adhering the antibacterial layer to the transparent colloid of the mixed layer. The staged acting antibacterial hydrogel dressing has the advantage of remarkable wound healing promoting effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a phase-acting antibacterial hydrogel dressing and a preparation method thereof. Background technique [0002] Medical dressings are wound dressings, medical materials used to cover sores, wounds or other damage. It can avoid the influence of bacterial infection and other external factors, and play a role in protecting the wound. The hydrogel in the hydrogel dressing can be firmly attached to the skin at the edge of the wound, and at the same time can absorb a large amount of wound exudate, which can solve the problem that the traditional gauze has too high permeability, which easily dehydrates and adheres to the wound surface, which will cause mechanical damage again when it is replaced. Injuries, microbes in the external environment are easy to pass through, and the chance of cross-infection is high. In addition, hydrogel dressings can also absorb wound exudate and some toxic substance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/44A61L15/24A61F13/02A61L15/18
Inventor 夏栋林顾海鹰何红李晓东陈燕培王雨飞陈超
Owner ARNOKANG NINGXIA BIOTECH
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