A kind of graphene oxide imitating cell outer membrane structure modification and preparation method thereof

A technology of imitating cell outer layer membrane and graphene is applied in the field of graphene oxide modified by imitating cell outer layer membrane structure and its preparation field, and achieves the effects of excellent biocompatibility, simple preparation method and broad application prospect.

Inactive Publication Date: 2016-09-07
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the degree of polymerization and grafting density of PEG are the key to restrict the biocompatibility of modified products, so that the modified materials still have immune response, which limits the application in vivo

Method used

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  • A kind of graphene oxide imitating cell outer membrane structure modification and preparation method thereof
  • A kind of graphene oxide imitating cell outer membrane structure modification and preparation method thereof
  • A kind of graphene oxide imitating cell outer membrane structure modification and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The structural formula of the graphene oxide modified by imitating the outer layer membrane structure of the present embodiment is:

[0030]

[0031] where X 1 and x 2 Both are O; R 1 and R 2 Both CH 3 ; 3 is a phosphorylcholine group; m / (m+p+q)=0.6.

[0032] The preparation method of the graphene oxide modified by the imitation cell outer layer membrane structure of the present embodiment is:

[0033] Step 1. Weigh 12mmol 2-methacryloyloxyethyl phosphorylcholine (MPC) and 8mmol 2-aminoethyl methacrylate hydrochloride, dissolve and mix with distilled water to obtain a mixed solution of monomers, Dissolve 0.1 mmol of potassium persulfate in distilled water to obtain an initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 12 hours, after the reaction is completed, concentrate the reaction solut...

Embodiment 2

[0039] This example is the same as Example 1, except that the polar solvent in step 2 is ethanol, the pH value is adjusted to 9, the temperature is 80° C., and the stirring reaction time is 16 hours.

Embodiment 3

[0041] The structural formula of the modified graphene oxide of the imitation cell outer layer membrane structure of the present embodiment is the same as that of Example 1, wherein the difference is: in the formula, R 1 and R 2 All are H, m / (m+p+q)=0.3.

[0042] The preparation method of the graphene oxide modified by the imitation cell outer layer membrane structure of the present embodiment is:

[0043] Step 1. Weigh 6mmol of acryloyloxyethylphosphorylcholine and 14mmol of 2-aminoethyl acrylate hydrochloride, dissolve and mix them uniformly in distilled water to obtain a mixed solution of monomers, and dissolve 0.1mmol of potassium persulfate in distilled water to obtain Initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 12 hours, after the reaction is completed, concentrate the reaction solution, and ...

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Abstract

The invention discloses a graphene oxide imitating the structure modification of the outer membrane of cells and a preparation method thereof, which is synthesized by a free radical polymerization method through vinyl monomers containing zwitterionic hydrophilic groups and vinyl monomers containing amino groups Binary random copolymers of - a zwitterionic polymer containing amino groups, grafting zwitterionic polymers containing amino groups onto the surface of graphene oxide can obtain graphite oxide with excellent biocompatibility imitating the structure of the outer membrane of cells Alkene, to avoid the residue of the initiator. The preparation method of the modified graphene oxide imitating cell outer membrane structure of the present invention is simple, the conditions are mild, and the post-treatment is simple, which provides a new way for obtaining a stable imitating cell outer membrane structure on the surface of graphene oxide , the graphene oxide modified with the imitation cell outer membrane structure will have broad application prospects in the fields of implant materials in vivo, tissue engineering, drug sustained release and biosensors.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a graphene oxide imitating the structure modification of the outer membrane of cells and a preparation method thereof. Background technique [0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface interaction ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L27/16A61K47/32G01N27/26
Inventor 宫铭蔡会武曲建林熊善新汪晓芹
Owner XIAN UNIV OF SCI & TECH
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